ArticleBioMed research international2015
Triphala Extract Suppresses Proliferation and Induces Apoptosis in Human Colon Cancer Stem Cells via Suppressing c-Myc/Cyclin D1 and Elevation of Bax/Bcl-2 Ratio.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Siddha formulations for cancer management: A review of preclinical and clinical data.Bioinformation · 2026Article
- The Multifaceted Benefits of Triphala: Uncovering Phytochemical and Pharmacological Properties From Antiquity to Modern Times.Chemistry & biodiversity · 2026Review
- Establishing a Novel Pyroptosis-related Gene Signature and Predicting Chemical Drugs for Papillary Thyroid Cancer.Current pharmaceutical biotechnology · 2025Article
- Triphala's characteristics and potential therapeutic uses in modern health.International journal of physiology, pathophysiology and pharmacology · 2025Review
- A comprehensive metabolome profiling of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica to explore the medicinal potential of Triphala.Scientific reports · 2024Article
- Inhibition of SARS-CoV-2-Induced NLRP3 Inflammasome-Mediated Lung Cell Inflammation by Triphala-Loaded Nanoparticle Targeting Spike Glycoprotein S1.Pharmaceutics · 2024Article
- Total Flavonoids inInternational journal of molecular sciences · 2023Article
- Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets.Cancer cell international · 2022Review
- Methionine restriction enhances the chemotherapeutic sensitivity of colorectal cancer stem cells by miR-320d/c-Myc axis.Molecular and cellular biochemistry · 2022Article
- GC-MS-employed phytochemical characterization, synergistic antioxidant, and cytotoxic potential of Triphala methanol extract at non-equivalent ratios of its constituents.Saudi journal of biological sciences · 2022Article
- Cancer Stem Cells: An Ever-Hiding Foe.Experientia supplementum (2012) · 2022Article
- Triphala extract negates arecoline-induced senescence in oral mucosal epithelial cells in vitro.Saudi journal of biological sciences · 2021Article
- BBS4 Is Essential for Nuclear Transport of Transcription Factors Mediating Neuronal ER Stress Response.Molecular neurobiology · 2021Article
- Protective Effect of Triphala against Oxidative Stress-Induced Neurotoxicity.BioMed research international · 2021Article
- Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology.International journal of molecular sciences · 2020Review
- Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala.Antioxidants (Basel, Switzerland) · 2020Review
- MiR-34b inhibits the proliferation and promotes apoptosis in colon cancer cells by targeting Wnt/β-catenin signaling pathway.Bioscience reports · 2019Article
- CDCA7L promotes glioma proliferation by targeting CCND1 and predicts an unfavorable prognosis.Molecular medicine reports · 2019Article
- Functions and Potential Applications of Circular RNAs in Cancer Stem Cells.Frontiers in oncology · 2019Review
- Chebulinic acid derived from triphala is a promising antitumour agent in human colorectal carcinoma cell lines.BMC complementary and alternative medicine · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Colon cancer is the second leading cause of cancer related deaths in the USA. Cancer stem cells (CSCs) have the ability to drive continued expansion of the population of malignant cells. Therefore, strategies that target CSCs could be effective against colon cancer and in reducing the risk of relapse and metastasis. In this study, we evaluated the antiproliferative and proapoptotic effects of triphala, a widely used formulation in Indian traditional medicine, on HCT116 colon cancer cells and human colon cancer stem cells (HCCSCs). The total phenolic content, antioxidant activity, and phytochemical composition (LC-MS-MS) of methanol extract of triphala (MET) were also measured. We observed that MET contains a variety of phenolics including naringin, quercetin, homoorientin, and isorhamnetin. MET suppressed proliferation independent of p53 status in HCT116 and in HCCSCs. MET also induced p53-independent apoptosis in HCCSCs as indicated by elevated levels of cleaved PARP. Western blotting data suggested that MET suppressed protein levels of c-Myc and cyclin D1, key proteins involved in proliferation, and induced apoptosis through elevation of Bax/Bcl-2 ratio. Furthermore, MET inhibited HCCSCs colony formation, a measure of CSCs self-renewal ability. Anticancer effects of triphala observed in our study warrant future studies to determine its efficacy in vivo.
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