ArticleBioMed research international2015
Can Variability of Pattern ERG Signal Help to Detect Retinal Ganglion Cells Dysfunction in Glaucomatous Eyes?
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Blue-Light Stimulation for Myopia Prevention: Only Retinal but Not Optic Disc Stimulation Modulates the Pattern ERG.Life (Basel, Switzerland) · 2025Article
- Retinal Vessel Diameter Reductions Are Associated with Retinal Ganglion Cell Dysfunction, Thinning of the Ganglion Cell and Inner Plexiform Layers, and Decreased Visual Field Global Indices in Glaucoma Suspects.Diagnostics (Basel, Switzerland) · 2025Article
- Pattern Electroretinogram in Ocular Hypertension, Glaucoma Suspect and Early Manifest Glaucoma Eyes: A Systematic Review and Meta-analysis.Ophthalmology science · 2023Article
- Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies.Frontiers in neuroscience · 2023Review
- Structure-function models for estimating retinal ganglion cell count using steady-state pattern electroretinography and optical coherence tomography in glaucoma suspects and preperimetric glaucoma: an electrophysiological pilot study.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- Associations between steady-state pattern electroretinography and estimated retinal ganglion cell count in glaucoma suspects.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- Retrograde Optic Nerve Degeneration in Pituitary Adenoma: A Study with RE-PERG.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- The role of pattern electroretinograms and optical coherence tomography angiography in the diagnosis of normal-tension glaucoma.Scientific reports · 2021Article
- Steady-State Pattern Electroretinography in Eyes with Glaucoma and High Myopia.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- RE-PERG in early-onset Alzheimer's disease: A double-blind, electrophysiological pilot study.PloS one · 2020Article
- Test-retest repeatability of the pattern electroretinogram and flicker electroretinogram.Documenta ophthalmologica. Advances in ophthalmology · 2019Article
- RE-PERG, a new paradigm for glaucoma diagnosis, in myopic eyes.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
- Noninvasive Prenatal Diagnosis Significance of ERG Methylation as a Biomarker in Down's Syndrome.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- RE-PERG, a new procedure for electrophysiologic diagnosis of glaucoma that may improve PERG specificity.Clinical ophthalmology (Auckland, N.Z.) · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate variability of steady-state pattern electroretinogram (SS-PERG) signal in normal, suspected, and glaucomatous eyes.
methodsTwenty-one subjects with suspected glaucoma due to disc abnormalities (GS), 37 patients with early glaucoma (EG), and 24 normal control (NC) were tested with spectral-domain optical coherence tomography (SD-OCT), standard automated perimetry (SAP), and SS-PERG. Mean deviation (MD), pattern standard deviation (PSD), retinal nerve fiber layer (RNFL), and ganglionar complex cells (GCC) were evaluated. The SS-PERG was recorded five consecutive times and the amplitude and phase of second harmonic were measured. PERG amplitude and coefficient of variation of phase (CVphase) were recorded, and correlation with structural and functional parameters of disease, by means of one-way ANOVA and Pearson's correlation, was analysed.
resultsPERG amplitude was reduced, as expression of retinal ganglion cells (RGCs) dysfunction, in EG patients and GS subjects compared to NC patients (P < 0.0001). CVphase was significantly increased in EG patients and GS subjects, compared to healthy (P < 0.0001), and it was also correlated with PSD (P = 0.0009), GCC (P = 0.028), and RNFL (P = 0.0078) only in EG patients.
conclusionsIncreased intrasession variability of phase in suspected glaucomatous eyes may be a sign of RGCs dysfunction.
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