ArticleAdipocyte
Acute induction of uncoupling protein 1 by citrulline in cultured explants of white adipose tissue from lean and high-fat-diet-fed rats.
Article in Adipocyte. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Quercetin and nanoquercetin mitigate high fat diet-induced obesity via lipid modulation, genomic DNA integrity restoration, adipokine regulation, and hepato-pancreatic tissue preservation.Scientific reports · 2026Article
- Integrated analysis of transcriptome and metabolome reveals the molecular interactions and regulation of muscle flavor precursors in Tengchong Snow chickens and AA broilers.Frontiers in veterinary science · 2026Article
- Anti-Obesity and Diuretic Effects of Immature Watermelon Rind Extract in HFD-Induced Obese Mice.Nutrients · 2025Article
- Integrated multi-omics reveals potential regulatory mechanisms of meat quality.Food chemistry. Molecular sciences · 2025Article
- Sex- and Dose-Dependent Effect of L-Citrulline on Body Weight and Food Intake in Obese Type 2 Diabetic Rats.International journal of endocrinology and metabolism · 2025Article
- Pharmacological modulation of RORα controls fat browning, adaptive thermogenesis, and body weight in mice.American journal of physiology. Endocrinology and metabolism · 2021Article
- Citrulline stimulates muscle protein synthesis, by reallocating ATP consumption to muscle protein synthesis.Journal of cachexia, sarcopenia and muscle · 2019Article
- Fibroblast Growth Factor 21 and Browning of White Adipose Tissue.Frontiers in physiology · 2019Review
- l-Citrulline Supplementation: Impact on Cardiometabolic Health.Nutrients · 2018Review
- Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management.British journal of pharmacology · 2017Review
- Citrulline counteracts overweight- and aging-related effects on adiponectin and leptin gene expression in rat white adipose tissue.Biochimie open · 2015Article
- What induces watts in WAT?AdipocyteReview
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A diet enriched with citrulline (CIT) reduces white adipose tissue (WAT) mass. We recently showed that CIT stimulated β-oxidation in rat WAT explants from young (2-4 months) but not old (25 months) rats. Here we show that both in old rats and high-fat-diet-fed young rats, uncoupling protein one (UCP1) mRNA and protein expressions were weaker than those in young control rats. Selectively in WAT from young rats, a 24h CIT treatment up-regulated expressions of UCP1, peroxisome proliferator-activated receptor-α (PPARα), PPARγ-coactivator-1-α and mitochondrial-transcription-factor-A whereas it down-regulated PPARγ2 gene expression, whatever the diet. These results suggest that CIT induces a new metabolic status in WAT, with increased β-oxidation and uncoupling of respiratory chain, resulting in energy expenditure that favors fat mass reduction.
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