ArticleBalkan medical journal2015
The Effects of Sugammadex on Progesterone Levels in Pregnant Rats.
Article in Balkan medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 27 citations in OpenAlex.
- Sugammadex in Perioperative Neuromuscular Management: Current Advances and Best Practices.Current pharmaceutical design · 2026Review
- Effects of Sugammadex and Neostigmine on Maternal Steroid and Lactation-Related Hormone Levels During Cesarean Section: A Randomized Clinical Trial.Journal of clinical practice and research · 2025Article
- What we need to know and do on sugammadex usage in pregnant and lactating women and those on hormonal contraceptives.Anesthesia and pain medicine · 2023Review
- A prospective observational study of the effects of sugammadex on peri-operative oestrogen and progesterone levels in women who take hormonal contraception.Anaesthesia · 2023Observational
- The Use of Muscle Relaxants in Pregnancy and Puerperium Period.International journal of general medicine · 2023Review
- General anaesthesia for nonobstetric surgery during pregnancy: A narrative review.European journal of anaesthesiology and intensive care · 2022Review
- Advantages and pitfalls of clinical application of sugammadex.Anesthesia and pain medicine · 2020Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSugammadex has been shown to decrease the efficiency of progesterone-containing oral contraceptive drugs which possess a steroid structure.
aimsThe aim of the present study was to evaluate the effects of sugammadex on progesterone levels in pregnant rats as well as on the physiological course of the pregnancy. STUDY
designAnimal experiment.
methodsThis study was approved by the Selçuk University Ethical Committee for Experimental Animal Research. Pregnant Winster Albino rats (n=26) were divided into three groups and administered with various intravenous injections on the 7(th) day of pregnancy. The control group (Group K, n=6) received 1.5 mL serum physiologic, the sugammadex group (Group S, n=10) received 30 mg/kg sugammadex and the sugammadex + rocuronium group (Group SR, n=10) received 30 mg/kg sugammadex and 3.5 mg/kg rocuronium. Progesterone levels were measured and the offspring were monitored for morphologic status.
resultsMean progesterone levels were 94.16±15.54 ng/mL in Group K, 87.86±12.48 ng/mL in Group S, and 94.53±16.10 ng/mL in Group SR (p>0.05). No stillbirth or miscarriage was observed in the rats. The mean number of offspring was 6.8±1.47 in Group K, 6.5±1.35 in Group S, and 6.4±1.17 in Group SR. The offspring appeared macroscopically normal.
conclusionSugammadex does not appear to affect the progesterone levels in pregnant rats in the first trimester and the clinical course. Successful completion of pregnancy and the absence of stillbirth or miscarriage will guide future studies about the use of sugammadex, particularly in the first trimester of the pregnancy.
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