Evidence map›Paper›PMID 26167290›Full record

ReviewLupus science & medicine2015

A highlight from the LUPUS 2014 meeting: eight great ideas.

Jill P Buyon, Phillip Cohen, Joan T Merrill, Gary Gilkeson, Mariana Kaplan, Judith James, W Joseph McCune, Sasha Bernatsky, Keith Elkon

Open access · goldAbstract readReview
In one paragraph

Review in Lupus science & medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. New Trials in Lupus and where Are we Going.Current rheumatology reports · 2018
    Review
  5. Review
  6. Review
  7. Effects of mannose-binding lectin on pulmonary gene expression and innate immune inflammatory response to ozone.American journal of physiology. Lung cellular and molecular physiology · 2016
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 2 countries.

Jill P BuyonDivision of Rheumatology, Department of Medicine , NYU School of Medicine , New York, New York , USA.
Phillip CohenDepartments of Medicine, Section of Rheumatology, Department of Microbiology and Immunology , Temple University School of Medicine , Philadelphia, Pennsylvania , USA.
Joan T MerrillClinical Pharmacology Research Program , Oklahoma Medical Research Foundation , Oklahoma City, Oklahoma , USA.
Gary GilkesonDepartment of Medicine , Medical University of South Carolina, Medical Research Service, Ralph H. Johnson VAMC , Charleston, South Carolina , USA.
Mariana KaplanSystemic Autoimmunity Branch , National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland , USA.
Judith JamesDepartment of Arthritis and Clinical Immunology , Oklahoma Medical Research Foundation , Oklahoma City, Oklahoma , USA.
W Joseph McCuneDepartment of Internal Medicine , University of Michigan Health System , Ann Arbor, Michigan , USA.
Sasha BernatskyDivisions of Rheumatology and Clinical Epidemiology , McGill University Health Centre , Montreal, Quebec , Canada.
Keith ElkonDepartments of Medicine and Immunology , University of Washington , Seattle, Washington , USA.
Oklahoma Medical Research Foundation · USMcGill University Health Centre · CAMedical University of South Carolina · USMichigan Medicine · USNational Institute of Arthritis and Musculoskeletal and Skin Diseases · USNew York University · USTemple University · USUniversity of Washington · US

Funding

Tracking and Evaluation CoreU54GM104938 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI PAUL G SPICER · 2013 to 2026
$68.2M
Systemic AutoimmunityZIAAR041199 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KAPLAN, MARIANA · 2014 to 2025
$32.5M
SNP Confirmation and High Throughput Genotyping CoreP30AR053483 · NIAMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GUTHRIDGE, JOEL MARVIN · 2007 to 2017
$6.7M
Pre-Clinical Studies to Identify SLE Therapeutic TargetsU19AI082714 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GAFFNEY, PATRICK M · 2009 to 2018
$6.2M
Science in a Culture of MentoringP30GM103510 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI JAMES, JUDITH A · 2012 to 2016
$3.9M
Understanding early events in lupus autoimmunity to aid preventionU01AI101934 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI JAMES, JUDITH A · 2012 to 2016
$2.3M
NIAID NIH HHS U01 AI101934NIAID NIH HHS U19 AI082714NIAMS NIH HHS P30 AR053483NIGMS NIH HHS P30 GM103510NIGMS NIH HHS U54 GM104938
6 · The paper itself

Abstract

This review describes eight 'great ideas' regarding bench-to-bedside considerations in systemic lupus erythematosus (SLE) presented at the second international LUPUS meeting in Quebec, September 2014. The topics included: correcting the impaired clearance of apoptotic fragments; optimisation of clinical trial design: the PERFECT (Pre Evaluation Reducing Frighteningly Elevated Coverable Targets) study; lipidomics and metabolomics in SLE; importance of the inflammasome; identification and treatment of asymptomatic autoimmunity: prevention of SLE; combining low doses of hydroxychloroquine and quinacrine for long-term maintenance therapy of SLE; reducing emergency room visits and the critical relevance of the autoantigen.

Indexed as

AutoimmunityDisease ActivityInflammationLupus NephritisSystemic Lupus Erythematosus

Identifiers

PMID26167290
PMCPMC4493165
OpenAlexW2119426740

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.