Evidence map›Paper›PMID 26167152›Full record

ReviewFrontiers in pharmacology2015

Central mechanisms mediating the hypophagic effects of oleoylethanolamide and N-acylphosphatidylethanolamines: different lipid signals?

Adele Romano, Bianca Tempesta, Gustavo Provensi, Maria B Passani, Silvana Gaetani

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  14. Symmetrically substituted dichlorophenes inhibitThe Journal of biological chemistry · 2020
    Article
  15. Diurnal Profiles ofFrontiers in neuroscience · 2019
    Article
  16. Endocannabinoids in Body Weight Control.Pharmaceuticals (Basel, Switzerland) · 2018
    Review
  17. Article
  18. Article
  19. Article
  20. The satiety factor oleoylethanolamide impacts hepatic lipid and glucose metabolism in goldfish.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Adele RomanoDepartment of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome , Rome,Italy.
Bianca TempestaDepartment of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome , Rome,Italy.
Gustavo ProvensiDepartment of Neuroscience, Psychology, Drug Discovery and Child Health (NEUROFARBA), University of Florence , Florence, Italy.
Maria B PassaniDepartment of Neuroscience, Psychology, Drug Discovery and Child Health (NEUROFARBA), University of Florence , Florence, Italy.
Silvana GaetaniDepartment of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome , Rome,Italy.
Sapienza University of Rome · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The spread of "obesity epidemic" and the poor efficacy of many anti-obesity therapies in the long-term highlight the need to develop novel efficacious therapy. This necessity stimulates a large research effort to find novel mechanisms controlling feeding and energy balance. Among these mechanisms a great deal of attention has been attracted by a family of phospholipid-derived signaling molecules that play an important role in the regulation of food-intake. They include N-acylethanolamines (NAEs) and N-acylphosphatidylethanolamines (NAPEs). NAPEs have been considered for a long time simply as phospholipid precursors of the lipid mediator NAEs, but increasing body of evidence suggest a role in many physiological processes including the regulation of feeding behavior. Several observations demonstrated that among NAEs, oleoylethanolamide (OEA) acts as a satiety signal, which is generated in the intestine, upon the ingestion of fat, and signals to the central nervous system. At this level different neuronal pathways, including oxytocinergic, noradrenergic, and histaminergic neurons, seem to mediate its hypophagic action. Similarly to NAEs, NAPE (with particular reference to the N16:0 species) levels were shown to be regulated by the fed state and this finding was initially interpreted as fluctuations of NAE precursors. However, the observation that exogenously administered NAPEs are able to inhibit food intake, not only in normal rats and mice but also in mice lacking the enzyme that converts NAPEs into NAEs, supported the hypothesis of a role of NAPE in the regulation of feeding behavior. Indirect observations suggest that the hypophagic action of NAPEs might involve central mechanisms, although the molecular target remains unknown. The present paper reviews the role that OEA and NAPEs play in the mechanisms that control food intake, further supporting this group of phospholipids as optimal candidate for the development of novel anti-obesity treatments.

Indexed as

histaminehypothalamusN-acylphosphatidylethanolaminesnucleus of the solitary tractobesityoleoylethanolamideoxytocinsatiety and food intake

Identifiers

PMID26167152
PMCPMC4481858
OpenAlexW1543511776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.