ArticleIEEE signal processing magazine2015
Quantitative Aspects of Single Molecule Microscopy.
Article in IEEE signal processing magazine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Measurement precision bounds on aberrated single-molecule emission patterns.Optics express · 2024Article
- Bayesian machine learning analysis of single-molecule fluorescence colocalization images.eLife · 2022Article
- A HIDDEN MARKOV MODEL APPROACH TO CHARACTERIZING THE PHOTO-SWITCHING BEHAVIOR OF FLUOROPHORES.The annals of applied statistics · 2019Article
- Facilitated Diffusion Mechanisms in DNA Base Excision Repair and Transcriptional Activation.Chemical reviews · 2018Review
- CRISPR-Cas9 Mediated Labelling Allows for Single Molecule Imaging and Resolution.Scientific reports · 2017Article
- Single-molecule analysis of steroid receptor and cofactor action in living cells.Nature communications · 2017Article
- Automatic optimal filament segmentation with sub-pixel accuracy using generalized linear models and B-spline level-sets.Medical image analysis · 2016Article
- New results on the single molecule localization problem in two and three dimensions.Proceedings of SPIE--the International Society for Optical Engineering · 2015Article
- Determination of localization accuracy based on experimentally acquired image sets: applications to single molecule microscopy.Optics express · 2015Article
- An information-theoretic approach to designing the plane spacing for multifocal plane microscopy.Proceedings of SPIE--the International Society for Optical Engineering · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Single molecule microscopy is a relatively new optical microscopy technique that allows the detection of individual molecules such as proteins in a cellular context. This technique has generated significant interest among biologists, biophysicists and biochemists, as it holds the promise to provide novel insights into subcellular processes and structures that otherwise cannot be gained through traditional experimental approaches. Single molecule experiments place stringent demands on experimental and algorithmic tools due to the low signal levels and the presence of significant extraneous noise sources. Consequently, this has necessitated the use of advanced statistical signal and image processing techniques for the design and analysis of single molecule experiments. In this tutorial paper, we provide an overview of single molecule microscopy from early works to current applications and challenges. Specific emphasis will be on the quantitative aspects of this imaging modality, in particular single molecule localization and resolvability, which will be discussed from an information theoretic perspective. We review the stochastic framework for image formation, different types of estimation techniques and expressions for the Fisher information matrix. We also discuss several open problems in the field that demand highly non-trivial signal processing algorithms.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.