ArticleJournal of Ayurveda and integrative medicine
Antihyperlipidemic activity of chickpea sprouts supplementation in ovariectomy-induced dyslipidemia in rats.
Article in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 24 citations in OpenAlex.
- The Germination Paradox in Sorghum: A Review.Foods (Basel, Switzerland) · 2026Review
- Development and Evaluation of Chickpea and Flaxseed-Based Porridge as a Dietary Intervention for Hyperlipidemia in Rats.Food science & nutrition · 2025Article
- Role of Seed Therapy on Estrous and Non-Estrous Cycle in Healthy Female Rats.Food science & nutrition · 2025Article
- Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy.Scientific reports · 2021Article
- Evaluation of the wound healing efficacy of chemical and phytogenic silver nanoparticles.IET nanobiotechnology · 2016Article
- Hepatoprotective Effect and Chemical Assessment of a Selected Egyptian Chickpea Cultivar.Frontiers in pharmacology · 2016Article
- Comparative clinical evaluation of Boerhavia diffusa root extract with standard Enalapril treatment in Canine chronic renal failure.Journal of Ayurveda and integrative medicineArticle
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPhytoestrogens are increasingly becoming popular as alternatives for hormone replacement therapy in postmenopausal condition.
objectiveIn this study, the antihyperlipidemic effect of chickpea (Cicer arientum) sprouts was evaluated in ovariectomy-induced dyslipidemia in rat model in comparison with standard antihyperlipidemic agent atorvastatin. MATERIALS AND
methodsA total of 24 female adult Wistar rats were divided into four groups that is, Group I - Control; Group II - Ovariectomized (OVX) rats; Group III - OVX + germinated chickpea sprouts (20% in diet) and Group IV OVX + atorvastatin (1.2 mg/kg b.wt, p.o.). Body and organ weights, serum, and liver lipid profile were assessed at the end of 8 weeks.
resultsThe results indicated that ovariectomy significantly (P < 0.05) increased total cholesterol, nonhigh-density lipoprotein cholesterol and triglycerides (TGs) in serum and liver. The total lipid and phospholipid content in liver were also significantly (P < 0.05) increased. The weights of uterus and heart were significantly (P < 0.05) decreased. Dietary supplementation with germinated chickpea normalized the lipid profile in serum and liver. Further, high-density lipoprotein (HDL) cholesterol, body weight, uterine, heart, and spleen weights were significantly (P < 0.05) increased. Atorvastatin administration showed similarly normalized lipid profile, but showed no improvement on decreased uterus and heart weights. Histopathological examination revealed fatty changes in liver, uterine atrophy, and subintimal fat accumulation in aorta in OVX group. The changes were mild in chickpea group with no improvement in statin group.
conclusionsGerminated seeds of chickpea showed significant antihyperlipidemic activity, which was comparable to atorvastatin. Further, germinated chickpea improved organ weights and helped in the reversal of histopathological changes suggesting its usefulness in postmenopausal condition.
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