ArticleMacromolecules2015
Kirkwood diffusivity of long semiflexible chains in nanochannel confinement.
Article in Macromolecules, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Simulations corroborate telegraph model predictions for the extension distributions of nanochannel confined DNA.Biomicrofluidics · 2019Article
- Nanoplumbing with 2D Metamaterials.Small (Weinheim an der Bergstrasse, Germany) · 2019Article
- Evaluation of Blob Theory for the Diffusion of DNA in Nanochannels.Macromolecules · 2018Article
- Hairpins in the conformations of a confined polymer.Biomicrofluidics · 2018Article
- Odijk excluded volume interactions during the unfolding of DNA confined in a nanochannel.Macromolecules · 2018Article
- Evidence for the extended de Gennes regime of a semiflexible polymer in slit confinement.Physical review. E · 2018Article
- The Statistical Segment Length of DNA: Opportunities for Biomechanical Modeling in Polymer Physics and Next-Generation Genomics.Journal of biomechanical engineering · 2018Article
- Simulations of knotting of DNA during genome mapping.Biomicrofluidics · 2017Article
- Modeling the relaxation of internal DNA segments during genome mapping in nanochannels.Biomicrofluidics · 2016Article
- Finite-size corrections for confined polymers in the extended de Gennes regime.Physical review. E, Statistical, nonlinear, and soft matter physics · 2015Article
- Measurements of DNA barcode label separations in nanochannels from time-series data.Biomicrofluidics · 2015Article
- DNA Brushing Shoulders: Targeted Looping and Scanning of Large DNA Strands.Nano letters · 2015Article
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Authors and funding
2 authors.
Funding
Abstract
We compute the axial diffusivity of asymptotically long semiflexible polymers confined in square channels. Our calculations employ the Kirkwood approximation of the mobility tensor by combining computational fluid dynamics (CFD) calculations of the hydrodynamic tensor in channel confinement with pruned-enriched Rosenbluth method (PERM) simulations of a discrete wormlike chain model. Three key results emerge from our study. First, for the classic de Gennes regime, we confirm that Brochard and de Gennes' blob theory correctly predicts the scaling of the axial diffusivity, contrary to the conclusions of previous analyses. Second, for the extended de Gennes regime, we show that a modified blob theory, which has been used to incorporate the effect of local stiffness on DNA diffusion in nanoslits, explains the deviation from the prediction of classic blob theory for diffusion in nanochannels. Third, we provide a calculation similar to the modified blob theory to explain the relative insensitivity of the diffusivity to channel size for channels between the extended de Gennes regime and the Odijk regime, which is the most relevant regime for experiments and technological applications of DNA confinement in nanochannels. Our results are not only relevant to the dynamics of confined semiflexible polymers such as DNA, but also reveal interesting analogies between confinement in channels and slits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.