ArticleCurrent biology : CB2015
Modeling the 3D geometry of the cortical surface with genetic ancestry.
Article in Current biology : CB, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Social media use and early adolescent brain structure: Findings from the Adolescent Brain Cognitive Development (ABCD) Study.NeuroImage · 2026Article
- Cortical gyrification deficits in early-stage Parkinson's disease: the importance of bradykinesia.Brain communications · 2026Article
- Cross-Species Cortical Geometry Reveals Conserved Gradients Across Primates and Human-Specific Expansion.bioRxiv : the preprint server for biology · 2025Article
- A common neural signature between genetic and environmental risk for mental illness.Translational psychiatry · 2025Article
- Comparative neurogenetics of dog behavior complements efforts towards human neuropsychiatric genetics.Human genetics · 2023Review
- Genotype Data and Derived Genetic Instruments of Adolescent Brain Cognitive Development StudyBehavior genetics · 2023Article
- Brain morphological variability between whites and African Americans: the importance of racial identity in brain imaging research.Frontiers in integrative neuroscience · 2023Article
- Generalization of cortical MOSTest genome-wide associations within and across samples.NeuroImage · 2022Article
- Chinese Color Nest Project : An accelerated longitudinal brain-mind cohort.Developmental cognitive neuroscience · 2021Review
- The effect of bilingualism on brain development from early childhood to young adulthood.Brain structure & function · 2020Article
- Constructing and evaluating a cortical surface atlas and analyzing cortical sex differences in young Chinese adults.Human brain mapping · 2020Article
- Baby brain atlases.NeuroImage · 2019Review
- Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data.Developmental cognitive neuroscience · 2018Review
- Williams Syndrome neuroanatomical score associates with GTF2IRD1 in large-scale magnetic resonance imaging cohorts: a proof of concept for multivariate endophenotypes.Translational psychiatry · 2018Article
- Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution.Human genetics · 2017Article
- ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide.NeuroImage · 2017Review
- Williams syndrome-specific neuroanatomical profile and its associations with behavioral features.NeuroImage. Clinical · 2017Article
- The heritability of chimpanzee and human brain asymmetry.Proceedings. Biological sciences · 2016Article
- Adolescent Development of Cortical and White Matter Structure in the NCANDA Sample: Role of Sex, Ethnicity, Puberty, and Alcohol Drinking.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Relaxed genetic control of cortical organization in human brains compared with chimpanzees.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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13 authors.
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Abstract
Knowing how the human brain is shaped by migration and admixture is a critical step in studying human evolution [1, 2], as well as in preventing the bias of hidden population structure in brain research [3, 4]. Yet, the neuroanatomical differences engendered by population history are still poorly understood. Most of the inference relies on craniometric measurements, because morphology of the brain is presumed to be the neurocranium's main shaping force before bones are fused and ossified [5]. Although studies have shown that the shape variations of cranial bones are consistent with population history [6-8], it is unknown how much human ancestry information is retained by the human cortical surface. In our group's previous study, we found that area measures of cortical surface and total brain volumes of individuals of European descent in the United States correlate significantly with their ancestral geographic locations in Europe [9]. Here, we demonstrate that the three-dimensional geometry of cortical surface is highly predictive of individuals' genetic ancestry in West Africa, Europe, East Asia, and America, even though their genetic background has been shaped by multiple waves of migratory and admixture events. The geometry of the cortical surface contains richer information about ancestry than the areal variability of the cortical surface, independent of total brain volumes. Besides explaining more ancestry variance than other brain imaging measurements, the 3D geometry of the cortical surface further characterizes distinct regional patterns in the folding and gyrification of the human brain associated with each ancestral lineage.
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