ArticleAmerican journal of human genetics2015
Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages.
Article in American journal of human genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Runs of Homozygosity Predict Inbreeding Depression Across Taxa: A Systematic Review and Meta-Analysis.Molecular ecology · 2026Pooled it
- Association between parental consanguineous marriage and the incidence, age of onset, and severity of coronary artery disease: a cross-sectional study in Iran.Korean journal of family medicine · 2026Article
- The Influence of Demographic History and Genetic Architecture on Complex Traits via Runs of Homozygosity.bioRxiv : the preprint server for biology · 2025Article
- Regional autozygosity association with albumin-to-creatinine ratio reveals a novel FTO region in an Indigenous Australian population.European journal of human genetics : EJHG · 2025Article
- Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank.eLife · 2024Article
- Identification of iron metabolism-related genes in coronary heart disease and construction of a diagnostic model.Frontiers in cardiovascular medicine · 2024Article
- Evaluation of imputation performance of multiple reference panels in a Pakistani population.medRxiv : the preprint server for health sciences · 2023Article
- Article
- Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish.BMC genomics · 2023Article
- Genome-wide analysis of runs of homozygosity in Pakistani controls with no history of speech or language-related developmental phenotypes.Annals of human biology · 2023Article
- COVID-19: Impact on linguistic and genetic isolates of India.Genes and immunity · 2022Article
- Further host-genomic characterization of total antibody response to PRRSV vaccination and its relationship with reproductive performance in commercial sows: genome-wide haplotype and zygosity analyses.Genetics, selection, evolution : GSE · 2021Article
- Genetic analysis of four consanguineous multiplex families with inflammatory bowel disease.Gastroenterology report · 2021Article
- Genomic partitioning of inbreeding depression in humans.American journal of human genetics · 2021Article
- Long runs of homozygosity are associated with Alzheimer's disease.Translational psychiatry · 2021Article
- Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank.medRxiv : the preprint server for health sciences · 2020Article
- Genome-wide association study of multiple yield traits in a diversity panel of polyploid sugarcane (Saccharum spp.).The plant genome · 2020Article
- Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population.Scientific reports · 2020Article
- AUDACITY: A comprehensive approach for the detection and classification of Runs of Homozygosity in medical and population genomics.Computational and structural biotechnology journal · 2020Article
- Ancestry-Dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity.American journal of human genetics · 2019Article
Corrections and comments
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Authors and funding
25 authors at 10 institutions in 6 countries.
Funding
Abstract
Runs of homozygosity (ROHs) are recognized signature of recessive inheritance. Contributions of ROHs to the genetic architecture of coronary artery disease and regulation of gene expression in cells relevant to atherosclerosis are not known. Our combined analysis of 24,320 individuals from 11 populations of white European ethnicity showed an association between coronary artery disease and both the count and the size of ROHs. Individuals with coronary artery disease had approximately 0.63 (95% CI: 0.4-0.8) excess of ROHs when compared to coronary-artery-disease-free control subjects (p = 1.49 × 10(-9)). The average total length of ROHs was approximately 1,046.92 (95% CI: 634.4-1,459.5) kb greater in individuals with coronary artery disease than control subjects (p = 6.61 × 10(-7)). None of the identified individual ROHs was associated with coronary artery disease after correction for multiple testing. However, in aggregate burden analysis, ROHs favoring increased risk of coronary artery disease were much more common than those showing the opposite direction of association with coronary artery disease (p = 2.69 × 10(-33)). Individual ROHs showed significant associations with monocyte and macrophage expression of genes in their close proximity-subjects with several individual ROHs showed significant differences in the expression of 44 mRNAs in monocytes and 17 mRNAs in macrophages when compared to subjects without those ROHs. This study provides evidence for an excess of homozygosity in coronary artery disease in outbred populations and suggest the potential biological relevance of ROHs in cells of importance to the pathogenesis of atherosclerosis.
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Registered trials
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