ArticleStructure (London, England : 1993)2015
Molecular Basis of MgATP Selectivity of the Mitochondrial SCaMC Carrier.
Article in Structure (London, England : 1993), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Magnesium as a Bioenergetic Checkpoint Linking Mitochondrial Function, Metabolic Disease, and Aging.Aging cell · 2026Review
- VEZT promotes pancreatic cancer progression by stabilizing SLC25A24 and preserving mitochondrial function.Frontiers in immunology · 2026Article
- The peculiar properties of mitochondrial carriers of the SLC25 family.The Biochemical journal · 2025Review
- Experimental Investigations on the Structure of Yeast Mitochondrial Pyruvate Carriers.Membranes · 2022Article
- NMR Characterization of Long-Chain Fatty Acylcarnitine Binding to the Mitochondrial Carnitine/Acylcarnitine Carrier.International journal of molecular sciences · 2022Article
- Mechanistic insights into multiple-step transport of mitochondrial ADP/ATP carrier.Computational and structural biotechnology journal · 2022Article
- Reply to 'Concerns with yeast mitochondrial ADP/ATP carrier's integrity in DPC' and 'Dynamics and interactions of AAC3 in DPC are not functionally relevant'.Nature structural & molecular biology · 2018Article
- Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies.Chemical reviews · 2018Review
- Article
- How Detergent Impacts Membrane Proteins: Atomic-Level Views of Mitochondrial Carriers in Dodecylphosphocholine.The journal of physical chemistry letters · 2018Article
- De Novo Mutations in SLC25A24 Cause a Craniosynostosis Syndrome with Hypertrichosis, Progeroid Appearance, and Mitochondrial Dysfunction.American journal of human genetics · 2017Article
- Mitochondrial ATP-Mg/phosphate carriers transport divalent inorganic cations in complex with ATP.Journal of bioenergetics and biomembranes · 2017Article
- Ion and inhibitor binding of the double-ring ion selectivity filter of the mitochondrial calcium uniporter.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A functional NMR for membrane proteins: dynamics, ligand binding, and allosteric modulation.Protein science : a publication of the Protein Society · 2016Review
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The mitochondrial matrix is the supplier of cellular ATP. The short Ca(2+)-binding mitochondrial carrier (SCaMC) is one of the two mitochondrial carriers responsible for transporting ATP across the mitochondrial inner membrane. While the ADP/ATP carrier (AAC) accounts for the bulk ADP/ATP recycling in the matrix, the function of SCaMC is important for mitochondrial activities that depend on adenine nucleotides, such as gluconeogenesis and mitochondrial biogenesis. A key difference between SCaMC and AAC is that SCaMC selectively transports MgATP whereas AAC only transports free nucleotides. Here, we use a combination of nuclear magnetic resonance experiments and functional mutagenesis to investigate the structural basis of the MgATP selectivity in SCaMC. Our data revealed an MgATP binding site inside the transporter cavity, while identifying an aspartic acid residue that plays an important role in the higher selectivity for MgATP over free ATP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.