ArticleJournal of theoretical biology2015
Morphogenetic implications of peristaltic fluid-tissue dynamics in the embryonic lung.
Article in Journal of theoretical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Thermal irreversibility and entropy generation analysis in MHD peristaltic transport of blood-based hybrid nanofluid through a curved duct.Discover nano · 2026Article
- Conserved Mechanisms in the Formation of the Airways and Alveoli of the Lung.Frontiers in cell and developmental biology · 2021Article
- Fgf10/Fgfr2b Signaling Orchestrates the Symphony of Molecular, Cellular, and Physical Processes Required for Harmonious Airway Branching Morphogenesis.Frontiers in cell and developmental biology · 2020Review
- Computational models of airway branching morphogenesis.Seminars in cell & developmental biology · 2017Review
- Overview of Lung Development in the Newborn Human.Neonatology · 2017Review
- Quantifying cellular and subcellular stretches in embryonic lung epithelia under peristalsis: where to look for mechanosensing.Interface focus · 2016Article
- Quantifying stretch and secretion in the embryonic lung: Implications for morphogenesis.Mechanisms of development · 2015Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Peristalsis begins in the lung as soon as the smooth muscle forms, and persists until birth. Since the prenatal lung is liquid-filled, smooth muscle action can deform tissues and transport fluid far from the immediately adjacent tissues. Stretching of embryonic tissues and sensation of internal fluid flows have been shown to have potent morphogenetic effects. We hypothesize that these effects are at work in lung morphogenesis. To place that hypothesis in a quantitative framework, we analyze a model of the fluid-structure interactions between embryonic tissues and lumen fluid resulting from peristaltic waves that partially occlude the airway. We find that if the airway is closed, deformations are synchronized; by contrast, if the trachea is open, maximal occlusion precedes maximal pressure. We perform a parametric analysis of how occlusion, stretch, and flow depend on tissue stiffnesses, smooth muscle force, tissue shape and size, and fluid viscosity. We find that most of these relationships are governed by simple ratios.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.