Evidence map›Paper›PMID 26165435›Full record

ArticleSexually transmitted diseases2015

Comparison of Antimicrobial Susceptibility of Urogenital Neisseria gonorrhoeae Isolates Obtained From Women and Men.

Sarah Kidd, Page C Moore, Robert D Kirkcaldy, Susan S Philip, Harold C Wiesenfeld, John R Papp, Peter R Kerndt, Lalitha Venkatasubramanian, Khalil G Ghanem, Edward W Hook

Abstract readComparative StudyMulticenter Study
In one paragraph

Article in Sexually transmitted diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Tetracycline-resistantJAC-antimicrobial resistance · 2025
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Sarah KiddFrom the *Centers for Disease Control and Prevention, Atlanta, GA; †University of Arkansas for Medical Sciences, Little Rock, AR; ‡San Francisco Department of Health, San Francisco, CA; §University of Pittsburgh and Allegheny County Health Department, Pittsburgh, PA; ¶County of Los Angeles, Department of Public Health, Los Angeles, CA; ∥FHI360, Durham, NC; **Johns Hopkins University School of Medicine, Baltimore, MD; and ††University of Alabama at Birmingham and Jefferson County Department of Health, Birmingham, AL.
Page C Moore
Robert D Kirkcaldy
Susan S Philip
Harold C Wiesenfeld
John R Papp
Peter R Kerndt
Lalitha Venkatasubramanian
Khalil G Ghanem
Edward W Hook
Centers for Disease Control and Prevention · USFamily Health International 360 · USLos Angeles County Department of Public Health · USSan Francisco Department of Public Health · USUniversity of Alabama at Birmingham · USUniversity of Arkansas for Medical Sciences · USUniversity of Pittsburgh · US

Funding

NIAID NIH HHS HHSN266200400074CPHS HHS HHSN 26620040073C
6 · The paper itself

Abstract

backgroundThe US system for gonococcal antimicrobial susceptibility surveillance monitors trends exclusively among men with urethral infection, the population from whom the yield of gonococcal culture is highest. Little is known about the susceptibility of female urogenital isolates, and it is unclear whether gonococcal susceptibility among men who report sex exclusively with women (MSW) is representative of susceptibility among women.

methodsUsing isolates collected during a recent treatment trial in 5 US cities, we performed a secondary analysis to compare antimicrobial susceptibilities of Neisseria gonorrhoeae urogenital isolates obtained from women, MSW, and men who have sex with men (MSM). Pretreatment isolates were collected from trial participants; minimum inhibitory concentrations (MICs) were determined by agar dilution. Geometric mean MICs were adjusted for geographic location using general linear models.

resultsSusceptibility data for urogenital isolates from 56 women, 252 MSW, and 170 MSM were studied. The adjusted geometric mean ceftriaxone MIC was similar among women (0.0067 μg/mL; 95% confidence interval [CI], 0.0049-0.0092 μg/mL) and MSW (0.0060 μg/mL; 95% CI, 0.0053-0.0066 μg/mL). In contrast, the adjusted geometric mean ceftriaxone MIC was higher among MSM (0.0098 μg/mL; 95% CI, 0.0082-0.0119 μg/mL) than among MSW. This same pattern was observed for other antimicrobials, including cefixime and azithromycin

conclusionsCeftriaxone, cefixime, and azithromycin MICs were higher among MSM than among MSW, but were similar among women and MSW. These findings suggest that gonococcal antimicrobial susceptibility surveillance based on urethral isolates from MSW may adequately represent susceptibility of urogenital N. gonorrhoeae in women.

Indexed as

HeterosexualityHomosexualityAdultAnti-Infective AgentsCiprofloxacinDrug Resistance, BacterialFemaleGonorrheaHumansMaleMicrobial Sensitivity TestsNeisseria gonorrhoeaePenicillinsSentinel SurveillanceTetracyclineUnited StatesAnti-Infective AgentsCiprofloxacinPenicillinsTetracycline

Identifiers

PMID26165435
PMCPMC4503381
OpenAlexW2409919461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.