Evidence map›Paper›PMID 26165414›Full record

ArticleBone2015

Influence of vitamin D and estrogen receptor gene polymorphisms on calcium absorption: BsmI predicts a greater decrease during energy restriction.

B Chang, Y Schlussel, D Sukumar, S H Schneider, S A Shapses

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Association between polymorphisms in vitamin D receptor gene and adolescent idiopathic scoliosis: a meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2018
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. The relationship between vitamin D receptor (VDR) polymorphism and the occurrence of osteoporosis in menopausal Iranian women.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

B ChangDepartment of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.
Y SchlusselDepartment of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.
D SukumarDrexel University, Philadelphia, PA, USA.
S H SchneiderDepartment of Medicine, Rutgers-Robert Wood Johnson University Hospital, USA.
S A ShapsesDepartment of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA. Electronic address: shapses@aesop.rutgers.edu.
Rutgers, The State University of New Jersey · USDrexel University · US

Funding

NUTRITIONAL REGULATION OF BONE TURNOVERR01AG012161 · NIA · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI SHAPSES, SUE AMY · 2000 to 2014
$3.4M
NUTRITIONAL REGULATION OF BONE TURNOVERR29AG012161 · NIA · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI SHAPSES, SUE AMY · 1994 to 1998
–
NIA NIH HHS AG12161NIA NIH HHS R01 AG012161
6 · The paper itself

Abstract

Low calcium absorption is associated with low bone mass and fracture. In this study, we use gold standard methods of fractional calcium absorption (FCA) to determine whether polymorphisms of intestinal receptors, vitamin D receptor (VDR) and estrogen receptor α (ESR1), influence the response to energy restriction. Fractional calcium absorption was measured using dual stable isotopes ((42)Ca and (43)Ca) in women given adequate calcium and vitamin D and examined at baseline and after 6 weeks of energy restriction or no intervention. After genotyping, the relationship between VDR and ESR1 genotypes/haplotypes and FCA response was assessed using several genetic models. One-hundred and sixty-eight women (53 ± 11 years of age) were included in this analysis. The ESR1 polymorphisms, PvuII and XbaI and VDR polymorphisms (TaqI, ApaI) did not significantly influence FCA. The BB genotype of the VDR polymorphism, BsmI, was associated with a greater decrease in FCA than the Bb/bb genotype. Multiple linear regression showed that the BsmI polymorphism or the VDR haplotype, BAt, in addition to changes in weight and vitamin D intake explained ~16% of the variation in changes in FCA. In conclusion, the reduction in calcium absorption due to energy restriction is greatest for those with the BB genotype. Previous candidate gene studies show that VDR polymorphisms are associated with higher risk for osteoporosis, and the current study supports the notion that the BsmI polymorphism in intestinal VDR may be contributing to alterations in bone health.

Indexed as

Polymorphism, GeneticAbsorptiometry, PhotonAdultAgedCalciumCaloric RestrictionEstrogen Receptor alphaFemaleGenotypeHumansMiddle AgedObesityPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthRadioimmunoassayReceptors, CalcitriolCalciumESR1 protein, humanEstrogen Receptor alphaReceptors, CalcitriolVDR protein, humanCalcium absorptionEstrogen receptor (ESR1)Gene polymorphismVitamin D receptor (VDR)

Identifiers

PMID26165414
PMCPMC4641000
OpenAlexW2165350754

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.