ArticleThe Pediatric infectious disease journal2015
Risk Factors for Community-associated Clostridium difficile-associated Diarrhea in Children.
Article in The Pediatric infectious disease journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Abundant geographical divergence of Clostridioides difficile infection in China: a prospective multicenter cross-sectional study.BMC infectious diseases · 2025Article
- Clostridium difficile infection in pediatric patients (Review).Biomedical reports · 2024Review
- Analysis of risk factors for community-acquiredTranslational pediatrics · 2023Article
- Antibiotic associated diarrhea in outpatient pediatric antibiotic therapy.BMC pediatrics · 2023Article
- Fidaxomicin Use in the Pediatric Population withClinical pharmacology : advances and applications · 2022Review
- Updates and Opinions in Diagnosis and Treatment ofCurrent treatment options in pediatrics · 2021Review
- Recurrent community-acquired Clostridium(Clostridioides)difficile infection in Serbianchildren.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Risk factors for Clostridioides (Clostridium) difficile infection following solid organ transplantation in children.Transplant infectious disease : an official journal of the Transplantation Society · 2019Article
- Risk factors for community-associated Clostridioides difficile infection in young children.Epidemiology and infection · 2019Article
- Clostridium difficile Whole Genome Sequencing Reveals Limited Transmission Among Symptomatic Children: A Single-Center Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Community-acquired Clostridium difficile infection in Serbian pediatric population.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- A retrospective study of community-acquired Clostridium difficile infection in southwest China.Scientific reports · 2018Article
- Recent Issues in Pediatric Clostridium difficile Infection.Current infectious disease reports · 2017Review
- Clostridium difficile infection in children: epidemiology and risk of recurrence in a low-prevalence country.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Observational
- Clostridium difficile Infection in Special High-Risk Populations.Infectious diseases and therapy · 2016Review
- The role of Clostridium difficile in the paediatric and neonatal gut - a narrative review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Review
- Clostridium difficile Infection in Pediatric Inflammatory Bowel Disease.Inflammatory bowel diseases · 2016Review
- An Updated Review of Clostridium difficile Treatment in Pediatrics.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundClostridium difficile-associated diarrhea (CDAD) is increasingly diagnosed in children in community settings. This study aims to assess recent antibiotic use and other risk factors in children with community-associated (CA-) CDAD compared with children with other diarrheal illnesses in a tertiary care setting.
methodsChildren with CA-CDAD evaluated at Texas Children's Hospital (Houston, TX) from January 1, 2012 to June 30, 2013 were identified. Two control subjects with community-associated diarrhea who tested negative for C. difficile were matched to case subjects. Data on demographics, medication exposure and outpatient healthcare encounters were collected from medical records. Multivariate logistic regression was performed to identify predictors of pediatric CA-CDAD.
resultsOf 69 CA-CDAD cases, most (62.3%) had an underlying chronic medical condition and 40.6% had antibiotic exposure within 30 days of illness. However, no traditional risk factor for CDAD was identified in 23.2% and 15.9% of CA-CDAD cases within 30 and 90 days of illness onset, respectively. Outpatient healthcare encounters within 30 days were more common among CA-CDAD cases than control subjects (66.7% vs. 48.6%; P = 0.01). In the final multivariate model, CA-CDAD was associated with cephalosporin use within 30 days [odds ratio: 3.32; 95% confidence interval: 1.10-10.01] and the presence of a gastrointestinal feeding device (odds ratio: 2.59; 95% confidence interval: 1.07-6.30).
conclusionsRecent use of cephalosporins and the presence of gastrointestinal feeding devices are important risk factors for community- associated CDAD in children. Reduction in the use of outpatient antibiotics may decrease the burden of CA-CDAD in children.
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