ArticleVirchows Archiv : an international journal of pathology2015
Consensus diagnostic histopathological criteria for acute gastrointestinal graft versus host disease improve interobserver reproducibility.
Article in Virchows Archiv : an international journal of pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Non-invasive diagnosis of acute intestinal graft-versus-host disease by a new scoring system using ultrasound morphology, compound elastography, and contrast-enhanced ultrasound.Bone marrow transplantation · 2019Trial
- A Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial of Oral Brincidofovir for Cytomegalovirus Prophylaxis in Allogeneic Hematopoietic Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019Trial
- Is Contrast-Enhanced Ultrasonography a New, Reliable Tool for Early-Graft-versus-Host Disease Diagnosis?Journal of clinical medicine · 2024Review
- Reproducibility of Rejection Grading in Uterus Transplantation: A Multicenter Study.Transplantation direct · 2023Article
- Round-Robin test for the histological diagnosis of acute colonic Graft-versus-Host disease validating established histological criteria and grading systems.Virchows Archiv : an international journal of pathology · 2023Article
- The clinical impact of donor against recipient HLA one way mismatch on the occurrence of graft versus host disease in liver transplantation.Scientific reports · 2022Article
- National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2020 Highly morbid forms report.Transplantation and cellular therapy · 2021Article
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- An association between crypt apoptotic bodies and mucosal flattening in celiac disease patients exposed to dietary gluten.Diagnostic pathology · 2019Article
- Histologic diagnosis and grading of esophageal acute graft-versus-host disease.Virchows Archiv : an international journal of pathology · 2019Article
- Current approach to early gastrointestinal and liver complications of hematopoietic stem cell transplantation.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Review
- Use of the National Institutes of Health Consensus Guidelines Improves the Diagnostic Sensitivity of Gastrointestinal Graft-Versus-Host Disease.Archives of pathology & laboratory medicine · 2018Article
- Inflammatory and infectious manifestations of immunodeficiency in the gastrointestinal tract.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Review
- Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence.Mediators of inflammation · 2018Review
- Graft-versus-Host Disease of the Gut: A Histologic Activity Grading System and Validation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2017Article
- Evaluation of crypt apoptotic bodies and apoptotic indices in pediatric celiac disease by routine staining and H2AX immunostaining.International journal of immunopathology and pharmacologyArticle
Corrections and comments
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Authors and funding
13 authors at 12 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graft versus host disease (GvHD) is a clinically important complication after allogeneic hematopoietic stem cell transplantation (HSCT). Its diagnosis relies on clinical and histopathological findings. In order to evaluate and improve inter-institutional diagnostic agreement on histological diagnosis and grading of acute gastrointestinal GvHD, we conducted a round robin test, which included 33 biopsies from 23 patients after HSCT. Five pathologists from different institutions independently evaluated the original sections from the biopsies submitted for diagnosis. Based on their results, consensus qualitative criteria for the assessment of typical histological features of GvHD (e.g., apoptosis, crypt destruction, mucosa denudation) were proposed, including detailed descriptions as well as histological images. In a second round robin test with involvement of the same pathologists, the reproducibility of both diagnosis and grading had improved. Remaining differences were mostly related to differential diagnostic considerations, including viral infection or toxic side effects of medication, which should be resolved by integrating histopathological findings with proper clinical information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.