Trial reportThe journal of allergy and clinical immunology. In practice
Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese.
Trial report in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Overweight, Obesity, and Lung Function in Children and Adults-A Meta-analysis.The journal of allergy and clinical immunology. In practicePooled it
- Distinguishing characteristics of difficult-to-control asthma in inner-city children and adolescents.The Journal of allergy and clinical immunology · 2016Trial
- Associations between body weight, asthma burden, and type 2 inflammation among under-resourced children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Pharmacogenetics of childhood uncontrolled asthma.Expert review of clinical immunology · 2025Review
- A clinician's guide to effects of obesity on childhood asthma and into adulthood.Expert review of respiratory medicine · 2024Review
- Exercise-Induced Bronchoconstriction in Children: State of the Art from Diagnosis to Treatment.Journal of clinical medicine · 2024Review
- ERS International Congress 2023: highlights from the Paediatrics Assembly.ERJ open research · 2024Article
- Breast feeding, obesity, and asthma association: clinical and molecular views.Clinical and molecular allergy : CMA · 2023Review
- Obesity-related pediatric asthma: relationships between pulmonary function and clinical outcomes.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Aging-Related Mechanisms Contribute to Corticosteroid Insensitivity in Elderly Asthma.International journal of molecular sciences · 2023Review
- Childhood Obesity and Respiratory Diseases: Which Link?Children (Basel, Switzerland) · 2021Review
- Atopy and pulmonary function among healthy-weight and overweight/obese children with asthma.Pediatric pulmonology · 2021Article
- Associations between overweight and obesity and asthma outcomes in urban adolescents.The Journal of asthma : official journal of the Association for the Care of Asthma · 2020Article
- Functional Genomics of the Pediatric Obese Asthma Phenotype Reveal Enrichment of Rho-GTPase Pathways.American journal of respiratory and critical care medicine · 2020Article
- Lung functional development and asthma trajectories.Seminars in immunopathology · 2020Review
- Obesity and asthma: risk, control and treatment.Postepy dermatologii i alergologii · 2018Review
- Gene Coexpression Networks in Whole Blood Implicate Multiple Interrelated Molecular Pathways in Obesity in People with Asthma.Obesity (Silver Spring, Md.) · 2018Article
- Obesity and asthma.The Journal of allergy and clinical immunology · 2018Review
- The effect of obesity, weight gain, and weight loss on asthma inception and control.Current opinion in allergy and clinical immunology · 2017Review
- Sex Differences in the Relationship between Fitness and Obesity on Risk for Asthma in Adolescents.The Journal of pediatrics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 11 institutions in 2 countries.
Funding
Abstract
backgroundFew studies have examined how developing obesity in early adulthood affects the course of asthma.
objectiveWe analyzed lung function and asthma impairment and risk among nonobese children with asthma, comparing those who were obese in young adulthood with those who remained nonobese.
methodsWe carried out the post hoc analysis of 771 subjects with mild to moderate asthma who were not obese (pediatric definition, body mass index [BMI] < 95th percentile) when enrolled in the Childhood Asthma Management Program at ages 5-12 years. The subjects were then followed to age 20 years or more. For visits at ages 20 years or more, spirometry values as percent predicted and recent asthma symptom scores and prednisone exposure were compared between 579 subjects who were nonobese at all visits and 151 who were obese (adult definition of BMI ≥ 30 kg/m(2)) on at least 1 visit (median number of visits when obese = 4, IQR 2-7).
resultsCompared with participants who were nonobese (BMI 23.4 ± 2.6 kg/m(2)), those who became obese (BMI 31.5 ± 3.8 kg/m(2)) had significant decreases in forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC) (P < .0003) and FEV1 (P = .001), without differences in FVC (P = .15) during visits at ages 20 years or more. For each unit increase of BMI, FEV1 percent predicted decreased by 0.29 (P = .0009). The relationship between BMI and lung function was not confounded by sex or BMI at baseline. Asthma impairment (symptom scores) and risk (prednisone use) did not differ between the 2 groups.
conclusionBecoming obese in early adulthood was associated with increased airway obstruction, without impact on asthma impairment or risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.