ReviewCurrent opinion in virology2015
Determinants of hepatitis B and delta virus host tropism.
Review in Current opinion in virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Mechanisms of Hepatitis B Virus cccDNA and Minichromosome Formation and HBV Gene Transcription.Viruses · 2024Review
- Structural basis of hepatitis B virus receptor binding.Nature structural & molecular biology · 2024Article
- Conversion of hepatitis B virus relaxed circular to covalently closed circular DNA is supported in murine cells.JHEP reports : innovation in hepatology · 2022Article
- Article
- Mechanism of Hepatitis B Virus cccDNA Formation.Viruses · 2021Review
- Animal Models for Hepatitis B: Does the Supply Meet the Demand?Gastroenterology · 2021Article
- Hepatitis B virus cccDNA is formed through distinct repair processes of each strand.Nature communications · 2021Article
- Woolly Monkey-HBV Infection in Squirrel Monkeys as a Surrogate Nonhuman Primate Model of HBV Infection.Hepatology communications · 2020Article
- Analysis of Host Responses to Hepatitis B and Delta Viral Infections in a Micro-scalable Hepatic Co-culture System.Hepatology (Baltimore, Md.) · 2020Article
- High prevalence and genetic diversity of hepatitis B viruses in insectivorous bats from China.Acta tropica · 2019Article
- Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection.Science translational medicine · 2018Article
- Long-term hepatitis B infection in a scalable hepatic co-culture system.Nature communications · 2017Article
- Hepatitis delta virus: insights into a peculiar pathogen and novel treatment options.Nature reviews. Gastroenterology & hepatology · 2016Review
- Hepatocarcinogenesis associated with hepatitis B, delta and C viruses.Current opinion in virology · 2016Review
- Approved Antiviral Drugs over the Past 50 Years.Clinical microbiology reviews · 2016Review
- Engineering Hepadnaviruses as Reporter-Expressing Vectors: Recent Progress and Future Perspectives.Viruses · 2016Review
- Hepatitis B Virus Infection of a Mouse Hepatic Cell Line Reconstituted with Human Sodium Taurocholate Cotransporting Polypeptide.Journal of virology · 2016Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Hepatitis B virus (HBV) infections are a global health problem afflicting approximately 360 million patients. Of these individuals, 15-20 million are co-infected with hepatitis delta virus (HDV). Progress toward curative therapies has been impeded by the highly restricted host tropism of HBV, which is limited to productive infections in humans and chimpanzees. Here, we will discuss different approaches that have been taken to study HBV and HDV infections in vivo. The development of transgenic and humanized mice has lead to deeper insights into HBV pathogenesis. An improved understanding of the determinants governing HBV and HDV species tropism will aid in the construction of a small animal model with inheritable susceptible to HBV/HDV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.