ReviewCurrent hypertension reports2015
Can drugs work in patients who do not take them? The problem of non-adherence in resistant hypertension.
Review in Current hypertension reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- When blood pressure refuses to budge: exploring the complexity of resistant hypertension.Frontiers in cardiovascular medicine · 2023Review
- Rethinking Resistant Hypertension.Journal of clinical medicine · 2022Review
- Evidence of Nonadherence in Cases of Pseudoresistant Hypertension.Integrated blood pressure control · 2021Article
- Clinicians' Values and Preferences for Medication Adherence and Cost Clinical Decision Support in Primary Care: A Qualitative Study.Applied clinical informatics · 2020Article
- The Prevalence of Nonadherence in Patients With Resistant Hypertension: A Systematic Review Protocol.Canadian journal of kidney health and disease · 2019Article
- Therapeutic drug monitoring-guided definition of adherence profiles in resistant hypertension and identification of predictors of poor adherence.British journal of clinical pharmacology · 2018Article
- Treating Hypertension in Diabetic Patients With Advanced Chronic Kidney Disease: What Should We Have in Mind?Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Drug Development for Hypertension: Do We Need Another Antihypertensive Agent for Resistant Hypertension?Current hypertension reports · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with uncontrolled hypertension on adequate combination and doses of blood pressure-lowering drugs present a diagnostic and therapeutic dilemma. Currently, hypertension guidelines point out uncommon causes of hypertension (either organic such as secondary hypertension or drugs/substances interfering with blood pressure-lowering drugs or causing hypertension) as a cause of hypertension resistance. Non-adherence to drugs, however, is equally, if not more, a cause of hypertension resistance. True resistance to pharmacotherapy is relatively uncommon, as in the majority of patients with non-adherence and/or secondary hypertension, the diagnosis of the problem may potentially lead to better control. Conventionally applied indirect methods to detect non-adherence are inadequate to uncover all cases of non-adherence, especially intentional non-adherence. Rigorous methods to detect non-adherence including direct observed therapy and measuring drug/metabolite levels in body fluids should be considered simultaneously if not before costly and invasive investigations for patients with difficult to control hypertension. However, data on the effectiveness of whether diagnosing non-adherence ultimately controls hypertension is still awaited.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.