Evidence map›Paper›PMID 26164422›Full record

Trial reportMaternal and child health journal2015

Dose and Timing of Prenatal Alcohol Exposure and Maternal Nutritional Supplements: Developmental Effects on 6-Month-Old Infants.

Claire D Coles, Julie A Kable, Carl L Keen, Kenneth Lyons Jones, Wladimir Wertelecki, Irina V Granovska, Alla O Pashtepa, Christina D Chambers, CIFASD

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Maternal and child health journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 7 pooled it
25.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 7 syntheses or guidelines pooled it, 125 citations in OpenAlex.

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  7. Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Claire D ColesDepartments of Psychiatry and Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. ccoles@emory.edu.ORCID http://orcid.org/0000-0003-3399-6644
Julie A KableDepartments of Psychiatry and Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Carl L KeenDepartment of Nutrition, University of California-Davis, Davis, CA, USA.
Kenneth Lyons JonesDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Wladimir WerteleckiDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Irina V GranovskaOMNI-Net for Children International Charitable Fund, Rivne Regional Medical Diagnostic Center, Rivne, Rivne Province, Ukraine.
Alla O PashtepaOMNI-Net for Children International Charitable Fund, Khmelnytsky Perinatal Center, Khmelnytsky, Khmelnytsky Province, Ukraine.
Christina D ChambersDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
CIFASD
University of California San Diego · USEmory University · USRivne State University of Humanities · UA

Funding

Whole Body Effects of PAE Across the Life Span: Early Markers of & Clinical Interventions for Children and Adolescents in UkraineU01AA014835 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHRISTINA CHAMBERS · 2003 to 2026
$12.1M
FASD Diagnostic Telemedicine ResourceU24AA014815 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Lauren Gist, SARAH N MATTSON WELLER · 2003 to 2026
$5.6M
Influence of nutrition on growth and neurodevelopment in children with FASDR01AA021551 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHAMBERS, CHRISTINA, KEEN, CARL L. · 2012 to 2016
$953k
NIAAA NIH HHS R01 AA021551NIAAA NIH HHS U01 AA014835NIAAA NIH HHS U01AA014835NIAAA NIH HHS U24 AA014815
6 · The paper itself

Abstract

objectivesFetal alcohol spectrum disorders are more common in disadvantaged populations. Environmental factors, like suboptimal nutrition, may potentiate the developmental effects of prenatal alcohol exposure. To evaluate the impact of micronutrients, including choline, on reduction of effects of exposure, we examined timing and dose of alcohol and effects of nutritional supplementation at two OMNI-Net sites in Western Ukraine that included high and low risk individuals.

methodsAlcohol-using and nondrinking women were randomized to one of three multivitamin/mineral supplement groups: none, multivitamins/minerals (MVM), and multivitamin/minerals plus choline. Children (N = 367) were tested at 6 months with the Bayley Scales of Infant Development (2nd ED) yielding standard scores for Mental Development Index (MDI), Psychomotor Development Index (PDI) and Behavior.

resultsGeneralized linear modeling was used: (1) for factorial analysis of effects of alcohol group, multivitamin/minerals, and choline supplementation; and (2) to examine the relationship between amount and timing of alcohol (ounces of absolute alcohol/day [ozAA/day] peri-conception and on average in the second trimester) and MVM supplementation on developmental outcomes while controlling sex, social class, and smoking. MDI was significantly impacted by peri-conceptual alcohol dose (X2(1), p < .001) with more alcohol associated with lower scores and males more negatively affected than females (X2(1), p < .002). Micronutrient supplementation had a protective effect; those receiving supplements performed better ([Formula: see text], p < .005). The PDI motor scores did not differ by group but were affected by peri-conceptual alcohol dose (X2(1), p < .04). CONCLUSIONS FOR PRACTICE: Multivitamin/mineral supplementation can reduce the negative impact of alcohol use during pregnancy on specific developmental outcomes.

Indexed as

Fetal Alcohol Spectrum DisordersChild DevelopmentDietary SupplementsFemaleHumansInfantMalePregnancyPrenatal Exposure Delayed EffectsPsychomotor PerformanceCholineFetal alcohol spectrum disordersInfant developmentMultivitamin supplementPrenatal alcohol exposure

Identifiers

PMID26164422
PMCPMC4644455
OpenAlexW1532048738

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.