Evidence map›Paper›PMID 26164215›Full record

ArticleJournal of cardiac failure2015

Intra-Aortic Balloon Counterpulsation in Patients With Chronic Heart Failure and Cardiogenic Shock: Clinical Response and Predictors of Stabilization.

Marc A Sintek, Mark Gdowski, Brian R Lindman, Michael Nassif, Kory J Lavine, Eric Novak, Richard G Bach, Scott C Silvestry, Douglas L Mann, Susan M Joseph

Abstract readComparative Study
In one paragraph

Article in Journal of cardiac failure, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 97 citations in OpenAlex.

  1. Review
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  4. The Intra-aortic Balloon Pump: A Focused Review of Physiology, Transport Logistics, Mechanics, and Complications.Journal of the Society for Cardiovascular Angiography & Interventions · 2024
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  16. Clinical and hemodynamic effects of intra-aortic balloon pump therapy in chronic heart failure patients with cardiogenic shock.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2018
    Article
  17. Differential responses to larger volume intra-aortic balloon counterpulsation: Hemodynamic and clinical outcomes.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2018
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Marc A SintekCardiovascular Division, Washington University School of Medicine, St Louis, Missouri.
Mark GdowskiDepartment of Medicine, Washington University School of Medicine, St Louis, Missouri.
Brian R LindmanCardiovascular Division, Washington University School of Medicine, St Louis, Missouri.
Michael NassifCardiovascular Division, Washington University School of Medicine, St Louis, Missouri.
Kory J LavineCardiovascular Division, Washington University School of Medicine, St Louis, Missouri.
Eric NovakCardiovascular Division, Washington University School of Medicine, St Louis, Missouri.
Richard G BachCardiovascular Division, Washington University School of Medicine, St Louis, Missouri.
Scott C SilvestryFlorida Hospital Transplant Institute, Orlando, Florida.
Douglas L MannCardiovascular Division, Washington University School of Medicine, St Louis, Missouri.
Susan M JosephCardiovascular Division, Washington University School of Medicine, St Louis, Missouri. Electronic address: sjoseph@dom.wustl.edu.
Washington University in St. Louis · US

Funding

PRINCIPLES IN CARDIVASCULAR RESEARCH TRAINING PROGRAMT32HL007081 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan, Karen Ellen Joynt Maddox · 1985 to 2026
$10.6M
CYTOPROTECTIVE EFFECTS OF INFLAMMATION MEDIATED MEMBRANE REPAIRR01HL111094 · NHLBI · WASHINGTON UNIVERSITY · PI MANN, DOUGLAS L · 2012 to 2016
$1.9M
EMBRYONIC-DERIVED MACROPHAGES IN CORONARY DEVELOPMENT AND ADULT CORONARY GROWTHK08HL123519 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2014 to 2018
$715k
PDE5 INHIBITION AS ADJUNCTIVE MEDICAL THERAPY IN AORTIC STENOSISK23HL116660 · NHLBI · WASHINGTON UNIVERSITY · PI LINDMAN, BRIAN RICHARD · 2013 to 2015
$450k
NHLBI NIH HHS 5T32HL007081-39NHLBI NIH HHS K08 HL123519NHLBI NIH HHS K23 HL116660NHLBI NIH HHS KO8 HL123519NHLBI NIH HHS R01 HL 111094NHLBI NIH HHS R01 HL111094NHLBI NIH HHS T32 HL007081
6 · The paper itself

Abstract

objectiveThe aim of this work was to characterize the clinical response and identify predictors of clinical stabilization after intra-aortic balloon counterpulsation (IABP) support in patients with chronic systolic heart failure in cardiogenic shock before implantation of a left ventricular assist device (LVAD).

backgroundLimited data exist regarding the clinical response to IABP in patients with chronic heart failure in cardiogenic shock.

methodsWe identified 54 patients supported with IABP before LVAD implantation. Criteria for clinical decompensation after IABP insertion and before LVAD included the need for more advanced temporary support, initiation of mechanical ventilation or dialysis, increase in vasopressors/inotropes, refractory ventricular arrhythmias, or worsening acidosis. The absence of these indicated stabilization.

resultsClinical decompensation after IABP occurred in 23 patients (43%). Both patients who decompensated and those who stabilized had similar hemodynamic improvements after IABP support, but patients who decompensated required more vasopressors/inotropes. Clinical decompensation after IABP was associated with worse outcomes after LVAD implantation, including a 3-fold longer intensive care unit stay and 5-fold longer time on mechanical ventilation (P < .01 for both). Although baseline characteristics were similar between groups, right and left ventricular cardiac power indexes (cardiac power index = cardiac index × mean arterial pressure/451) identified patients who were likely to stabilize (area under the receiver operating characteristic curve = 0.82).

conclusionsAmong patients with chronic systolic heart failure who develop cardiogenic shock, more than one-half of patients stabilized with IABP support as a bridge to LVAD. Baseline measures of right and left ventricular cardiac power, reflecting work performed for a given flow and pressure, may allow clinicians to identify patients with sufficient contractile reserve who will be likely to stabilize with an IABP versus those who may need more aggressive ventricular support.

Indexed as

AgedCause of DeathChronic DiseaseCohort StudiesDisease ProgressionFemaleFollow-Up StudiesHeart-Assist DevicesHeart FailureHemodynamicsHospital MortalityHumansIntra-Aortic Balloon PumpingKaplan-Meier EstimateMaleMiddle Agedcardiogenic shockheart failureIABPIntra-aortic balloon counterpulsationleft ventricular device implantationpercutaneous support

Identifiers

PMID26164215
PMCPMC4630130
OpenAlexW2099400305

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.