ArticleDrug and alcohol dependence2015
A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [(11)C](+)PHNO.
Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Chronic social stressors and striatal dopamine functioning in humans: A systematic review of SPECT and PET studies.Molecular psychiatry · 2024Pooled it
- Neuroimaging evidence for a dopamine-independent association between motor cortex microstructure and Parkinson's disease severity.NPJ Parkinson's disease · 2026Article
- Measuring Dopamine Transporter Availability and Synaptic Density in Parkinson's Disease: A Dual-Tracer Positron Emission Tomography Imaging Study.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Socioenvironmental Factors are Associated With Dopamine Transporter Availability in Healthy Individuals but not in Parkinson's Disease.Journal of geriatric psychiatry and neurology · 2025Article
- Synaptic loss and its association with symptom severity in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Clinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [Brain communications · 2024Article
- Relationships between dopamine D2/3 receptor availability and social-environmental factors in humans.Neuroscience letters · 2022Article
- Effects of moderate-intensity exercise on social health and physical and mental health of methamphetamine-dependent individuals: A randomized controlled trial.Frontiers in psychiatry · 2022Article
- Dopamine dysfunction in stimulant use disorders: mechanistic comparisons and implications for treatment.Molecular psychiatry · 2022Review
- Dopamine DDrug and alcohol dependence · 2021Article
- Separating dopamine DNeuroImage · 2020Article
- Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging.Annals of neurology · 2020Article
- Is There a Role for GPCR Agonist Radiotracers in PET Neuroimaging?Frontiers in molecular neuroscience · 2019Review
- Brain neuroreceptor density and personality traits: towards dimensional biomarkers for psychiatric disorders.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Neural and Endocrine Correlates of Early Life Abuse in Youth With Depression and Obesity.Frontiers in psychiatry · 2018Article
- Exploring the relationship between social attachment and dopamine DSocial neuroscience · 2017Article
- Regional and source-based patterns of [NeuroImage · 2017Article
- Histidine Decarboxylase Knockout Mice as a Model of the Pathophysiology of Tourette Syndrome and Related Conditions.Handbook of experimental pharmacology · 2017Review
- Elevated Dopamine DNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrevious work in healthy non-human primates and humans has shown that social status correlates positively with dopamine 2/3 receptor (D2/3R) availability imaged with antagonist radioligands and positron emission tomography (PET). Further work in non-human primates suggests that this relationship is disrupted by chronic cocaine administration. This exploratory study examined the relationship between social status and D2/3R availability in healthy (HH) and cocaine dependent (CD) humans using the D3-preferring, agonist radioligand, [(11)C](+)PHNO.
methodsSixteen HH and sixteen CD individuals completed the Barratt Simplified Measure of Social Status (BSMSS) and underwent [(11)C](+)PHNO scanning to measure regional brain D2/3R binding potentials (BPND). Correlations between BPND and BSMSS scores were then assessed within each group.
resultsWithin HH and CD groups, inverse associations between BSMSS score and BPND were observed in the substantia nigra/ventral tegmental area (SN/VTA) and the ventral striatum, and for the CD group alone, the amygdala. After adjusting for body mass index and age, negative correlations remained significant in the SN/VTA for HH and in the amygdala for CD subjects.
conclusionThese preliminary data utilizing a dopamine agonist tracer demonstrate, for the first time, an inverse association between social status and D2/3R availability in the D3R rich extrastriatal regions of HH and CD humans.
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