Evidence map›Paper›PMID 26164200›Full record

ArticleBrain, behavior, and immunity2015

Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome.

P L Gambús, I F Trocóniz, X Feng, M Gimenez-Milá, R Mellado, V Degos, S Vacas, M Maze

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Interventions to improve perioperative neurologic outcomes.Current opinion in anaesthesiology · 2020
    Review
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

P L GambúsDepartment of Anesthesia and Perioperative Care, University of California San Francisco (UCSF), San Francisco, CA, USA; Systems Pharmacology Effect Control & Modeling (SPEC-M) Research Group, Anesthesiology Department, Hospital CLINIC de Barcelona, Barcelona, Spain; NeuroImmunology Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Electronic address: plgambus@clinic.ub.es.
I F TrocónizDepartment of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Universidad de Navarra, Pamplona, Spain.
X FengDepartment of Anesthesia and Perioperative Care, University of California San Francisco (UCSF), San Francisco, CA, USA.
M Gimenez-MiláSystems Pharmacology Effect Control & Modeling (SPEC-M) Research Group, Anesthesiology Department, Hospital CLINIC de Barcelona, Barcelona, Spain.
R MelladoSystems Pharmacology Effect Control & Modeling (SPEC-M) Research Group, Anesthesiology Department, Hospital CLINIC de Barcelona, Barcelona, Spain.
V DegosDepartment of Anesthesia and Perioperative Care, University of California San Francisco (UCSF), San Francisco, CA, USA; Department of Anesthesiology and Critical Care, Hôpital Pitié Salpetrière, Assistance Publique-Hopitaux de Paris (APHP), Université Pierre et Marie Curie-Paris VI and UMR INSERM 1141, Paris, France.
S VacasDepartment of Anesthesia and Perioperative Care, University of California San Francisco (UCSF), San Francisco, CA, USA.
M MazeDepartment of Anesthesia and Perioperative Care, University of California San Francisco (UCSF), San Francisco, CA, USA.

Funding

Inflammation resolving mechanism dysregulation in postoperative cognitive declineR01GM104194 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAZE, MERVYN · 2013 to 2016
$1.2M
NIGMS NIH HHS R01 GM104194NIGMS NIH HHS R01GM104194
6 · The paper itself

Abstract

introductionThe relationship between persistent postoperative cognitive decline and the more common acute variety remains unknown; using data acquired in preclinical studies of postoperative cognitive decline we attempted to characterize this relationship.

methodsLow capacity runner (LCR) rats, which have all the features of the metabolic syndrome, were compared postoperatively with high capacity runner (HCR) rats for memory, assessed by trace fear conditioning (TFC) on the 7th postoperative day, and learning and memory (probe trial [PT]) assessed by the Morris water-maze (MWM) at 3 months postoperatively. Rate of learning (AL) data from the MWM test, were estimated by non-linear mixed effects modeling. The individual rat's TFC result at postoperative day (POD) 7 was correlated with its AL and PT from the MWM data sets at postoperative day POD 90.

resultsA single exponential decay model best described AL in the MWM with LCR and surgery (LCR-SURG) being the only significant covariates; first order AL rate constant was 0.07 s(-1) in LCR-SURG and 0.16s(-1) in the remaining groups (p<0.05). TFC was significantly correlated with both AL (R=0.74; p<0.0001) and PT (R=0.49; p<0.01).

conclusionSeverity of memory decline at 1 week after surgery presaged long-lasting deteriorations in learning and memory.

Indexed as

AnimalsCognition DisordersConditioning, ClassicalFearHindlimbMaze LearningMemoryMetabolic DiseasesPostoperative ComplicationsRatsTime FactorsAcuteCognitive declineLearningLong termMemoryMetabolic syndromePostsurgical

Identifiers

PMID26164200
PMCPMC4631699

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.