ArticleJournal of biomechanics2015
Effects of normal and abnormal loading conditions on morphogenesis of the prenatal hip joint: application to hip dysplasia.
Article in Journal of biomechanics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Computation of Fetal Kicking in Various Fetal Health Examinations: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Computational mechanobiological model combining epiphyseal, apophyseal, and appositional growth and inner bone remodeling of the juvenile femur.Biomedical engineering online · 2026Article
- Modeling endochondral ossification: Effects of mechanical loading and bone shape.Journal of orthopaedics · 2025Article
- Mechanical deformations of bone generate interstitial fluid flow at nanoscale velocities around osteocytes.Frontiers in bioengineering and biotechnology · 2025Article
- Compressive stress gradients direct mechanoregulation of anisotropic growth in the zebrafish jaw joint.PLoS computational biology · 2024Article
- Arthritis Foundation/HSS Workshop on Hip Osteoarthritis, Part 1: Epidemiology, Early Development, and Cohorts From Around the World.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2023Review
- Neonatal Hip Loading in Developmental Dysplasia: Finite Element Simulation of Proximal Femur Growth and Treatment.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2023Article
- Optogenetic-Induced Muscle Loading Leads to Mechanical Adaptation of the Achilles Tendon Enthesis in Mice.bioRxiv : the preprint server for biology · 2023Article
- A numerical study towards shape memory alloys application in orthotic management of pediatric knee lateral deviations.Scientific reports · 2023Article
- Building a Co-ordinated Musculoskeletal System: The Plasticity of the Developing Skeleton in Response to Muscle Contractions.Advances in anatomy, embryology, and cell biology · 2023Article
- Growth orientations, rather than heterogeneous growth rates, dominate jaw joint morphogenesis in the larval zebrafish.Journal of anatomy · 2022Article
- Local mechanical stimuli correlate with tissue growth in axolotl salamander joint morphogenesis.Proceedings. Biological sciences · 2022Article
- A Preliminary Cadaveric MRI Study of Fetal Hip Development.Frontiers in surgery · 2022Article
- The role of computational models in mechanobiology of growing bone.Frontiers in bioengineering and biotechnology · 2022Article
- Collagen I in the Hip Capsule Plays a Role in Postoperative Clinical Function in Patients With Developmental Dysplasia of the Hip.Frontiers in pediatrics · 2022Article
- Total Hip Replacement in Sickle Cell Disease Patients with Avascular Necrosis of Head of Femur: A Retrospective Observational Study.Indian journal of orthopaedics · 2021Article
- The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis.Calcified tissue international · 2021Review
- A comparative radiographic morphometric analysis to assess the normal radiological morphology of the adult hip in indian population.Journal of clinical orthopaedics and trauma · 2021Article
- Preganglionic and Postganglionic Brachial Plexus Birth Injury Effects on Shoulder Muscle Growth.The Journal of hand surgery · 2021Article
- Integrated iterative musculoskeletal modeling predicts bone morphology following brachial plexus birth injury (BPBI).Journal of biomechanics · 2020Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Joint morphogenesis is an important phase of prenatal joint development during which the opposing cartilaginous rudiments acquire their reciprocal and interlocking shapes. At an early stage of development, the prenatal hip joint is formed of a deep acetabular cavity that almost totally encloses the head. By the time of birth, the acetabulum has become shallower and the femoral head has lost substantial sphericity, reducing joint coverage and stability. In this study, we use a dynamic mechanobiological simulation to explore the effects of normal (symmetric), reduced and abnormal (asymmetric) prenatal movements on hip joint shape, to understand their importance for postnatal skeletal malformations such as developmental dysplasia of the hip (DDH). We successfully predict the physiological trends of decreasing sphericity and acetabular coverage of the femoral head during fetal development. We show that a full range of symmetric movements helps to maintain some of the acetabular depth and femoral head sphericity, while reduced or absent movements can lead to decreased sphericity and acetabular coverage of the femoral head. When an abnormal movement pattern was applied, a deformed joint shape was predicted, with an opened asymmetric acetabulum and the onset of a malformed femoral head. This study provides evidence for the importance of fetal movements in the prevention and manifestation of congenital musculoskeletal disorders such as DDH.
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