ArticleSchizophrenia bulletin2016
EEG-Informed fMRI Reveals a Disturbed Gamma-Band-Specific Network in Subjects at High Risk for Psychosis.
Article in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Effects of N-Methyl-d-Aspartate Receptor Antagonists on Gamma-Band Activity During Auditory Stimulation Compared With Electro/Magneto-encephalographic Data in Schizophrenia and Early-Stage Psychosis: A Systematic Review and Perspective.Schizophrenia bulletin · 2024Pooled it
- Transcranial alternating current stimulation (tACS): from basic mechanisms towards first applications in psychiatry.European archives of psychiatry and clinical neuroscience · 2021Pooled it
- EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Reduced auditory evoked gamma-band response and schizophrenia-like clinical symptoms under subanesthetic ketamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- Multimodal EEG-MRI Neuroimaging in Schizophrenia-A Systematic and Mechanistic Review.Journal of clinical medicine · 2026Review
- Transient juvenile demyelination impairs maturation and function of parvalbumin-positive interneurons in the prefrontal cortex.PLoS biology · 2025Article
- Simultaneous EEG-fMRI Reveals a Visual Working Memory Encoding Network Related to Theta Oscillatory Activity in Healthy Subjects.Human brain mapping · 2025Article
- Trajectories of working memory and decision making abilities along juvenile development in mice.Frontiers in neuroscience · 2025Article
- Challenges and Approaches in the Study of Neural Entrainment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- The Pathophysiological Underpinnings of Gamma-Band Alterations in Psychiatric Disorders.Life (Basel, Switzerland) · 2024Review
- The decoupling of structural and functional connectivity of auditory networks in individuals at clinical high-risk for psychosis.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2023Article
- Gamma oscillations provide insights into cortical circuit development.Pflugers Archiv : European journal of physiology · 2023Review
- The psychotomimetic ketamine disrupts the transfer of late sensory information in the corticothalamic network.The European journal of neuroscience · 2023Article
- Opposite Modulation of the NMDA Receptor by Glycine and S-Ketamine and the Effects on Resting State EEG Gamma Activity: New Insights into the Glutamate Hypothesis of Schizophrenia.International journal of molecular sciences · 2023Article
- Delayed closed-loop neurostimulation for the treatment of pathological brain rhythms in mental disorders: a computational study.Frontiers in neuroscience · 2023Article
- The Association between Electroencephalography with Auditory Steady-State Response and Postoperative Delirium.Journal of personalized medicine · 2022Article
- Test-retest reliability of tone- and 40 Hz train-evoked gamma oscillations in female rats and their sensitivity to low-dose NMDA channel blockade.Psychopharmacology · 2021Article
- Article
- Cellular and extracellular white matter alterations indicate conversion to psychosis among individuals at clinical high-risk for psychosis.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2021Article
- Effects of iTBS-rTMS on the Behavioral Phenotype of a Rat Model of Maternal Immune Activation.Frontiers in behavioral neuroscience · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAbnormalities of oscillatory gamma activity are supposed to reflect a core pathophysiological mechanism underlying cognitive disturbances in schizophrenia. The auditory evoked gamma-band response (aeGBR) is known to be reduced across all stages of the disease. The present study aimed to elucidate alterations of an aeGBR-specific network mediated by gamma oscillations in the high-risk state of psychosis (HRP) by means of functional magnetic resonance imaging (fMRI) informed by electroencephalography (EEG).
methodsEEG and fMRI were simultaneously recorded from 27 HRP individuals and 26 healthy controls (HC) during performance of a cognitively demanding auditory reaction task. We used single trial coupling of the aeGBR with the corresponding blood oxygen level depending response (EEG-informed fMRI).
resultsA gamma-band-specific network was significantly lower active in HRP subjects compared with HC (random effects analysis, P < .01, Bonferroni-corrected for multiple comparisons) accompanied by a worse task performance. This network involved the bilateral auditory cortices, the thalamus and frontal brain regions including the anterior cingulate cortex, as well as the bilateral dorsolateral prefrontal cortex.
conclusionsFor the first time we report a reduced activation of an aeGBR-specific network in HRP subjects brought forward by EEG-informed fMRI. Because the HRP reflects the clinical risk for conversion to psychotic disorders including schizophrenia and the aeGBR has repeatedly been shown to be altered in patients with schizophrenia the results of our study point towards a potential applicability of aeGBR disturbances as a marker for the prediction of transition of HRP subjects to schizophrenia.
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