Trial reportEuropean journal of nutrition2016
Phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of phenolic acids on vascular smooth muscle cells in vitro.
Trial report in European journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06332222 (Recovery With Tart Cherry Supplementation Following a Marathon.), which is not on this map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Recovery With Tart Cherry Supplementation Following a Marathon.
Who cites it
43 citing papers in PubMed, 81 citations in OpenAlex.
- Recovery with vistula tart cherries following a marathon.European journal of nutrition · 2026Trial
- Tart cherry supplementation causes differential regulation of skeletal muscle proteome after eccentric exercise.Frontiers in nutrition · 2026Trial
- Acute Dosing Strategy with Vistula Tart Cherries for Recovery of Strenuous Exercise-A Feasibility Study.Nutrients · 2024Trial
- Trial
- The Influence of Tart Cherry (Nutrients · 2021Trial
- Effects of short-term continuous Montmorency tart cherry juice supplementation in participants with metabolic syndrome.European journal of nutrition · 2021Trial
- Acute Ingestion of Montmorency Tart Cherry Reduces Serum Uric Acid but Has no Impact on High Sensitivity C-Reactive Protein or Oxidative Capacity.Plant foods for human nutrition (Dordrecht, Netherlands) · 2021Trial
- The influence of tart cherries (Journal of nutritional science · 2021Trial
- Effects of Tart Cherry Juice on Biomarkers of Inflammation and Oxidative Stress in Older Adults.Nutrients · 2019Trial
- Montmorency cherry supplementation attenuates vascular dysfunction induced by prolonged forearm occlusion in overweight, middle-aged men.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Trial
- Cardiovascular function during supine rest in endurance-trained males with New Zealand blackcurrant: a dose-response study.European journal of applied physiology · 2017Trial
- The Effects of Montmorency Tart Cherry Concentrate Supplementation on Recovery Following Prolonged, Intermittent Exercise.Nutrients · 2016Trial
- Anthocyanin-Induced Alterations in Substrate Oxidation During Exercise: A Narrative Review.Nutrients · 2026Review
- Tart Cherry (International journal of molecular sciences · 2025Article
- A Comprehensive Polyphenolic Characterization of Five Montmorency Tart Cherry (Foods (Basel, Switzerland) · 2025Article
- Montmorency cherry supplementation enhances 15 km cycling time trial performance: Optimal timing 90-min pre-exercise.European journal of sport science · 2024Article
- Phenolic Compounds from Cherries and Berries for Chronic Disease Management and Cardiovascular Risk Reduction.Nutrients · 2024Review
- Bioavailability of Anthocyanins: Whole Foods versus Extracts.Nutrients · 2024Review
- Effects ofFrontiers in molecular biosciences · 2024Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of selected phenolic acids on vascular smooth muscle cells in vitro.
methodsIn a randomised, double-blinded, crossover design, 12 healthy males consumed either 30 or 60 mL of Montmorency tart cherry concentrate. Following analysis of the juice composition, venous blood samples were taken before and 1, 2, 3, 5 and 8 h post-consumption of the beverage. In addition to examining some aspects of the concentrate contents, plasma concentrations of protocatechuic acid (PCA), vanillic acid (VA) and chlorogenic (CHL) acid were analysed by reversed-phase high-performance liquid chromatography (HPLC) with diode array for quantitation and mass spectrometry detection (LCMS) for qualitative purposes. Vascular smooth muscle cell migration and proliferation were also assessed in vitro.
resultsBoth the 30 and 60 mL doses of Montmorency cherry concentrate contained high amounts of total phenolics (71.37 ± 0.11; 142.73 ± 0.22 mg/L) and total anthocyanins (62.47 ± 0.31; 31.24 ± 0.16 mg/L), as well as large quantities of CHL (0.205 ± 0.24; 0.410 ± 0.48 mg/L) and VA (0.253 ± 0.84; 0.506 ± 1.68 mg/L). HPLC/LCMS identified two dihydroxybenzoic acids (PCA and VA) in plasma following MC concentrate consumption. Both compounds were most abundant 1-2 h post-initial ingestion with traces detectable at 8 h post-ingestion. Cell migration was significantly influenced by the combination of PCA and VA, but not in isolation. There was no effect of the compounds on cell proliferation.
conclusionsThese data show new information that phenolic compounds thought to exert vasoactive properties are bioavailable in vivo following MC consumption and subsequently can influence cell behaviour. These data may be useful for the design and interpretation of intervention studies investigating the health effects of Montmorency cherries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.