ArticleEukaryotic cell2015
Activation of Autophagy by Metals in Chlamydomonas reinhardtii.
Article in Eukaryotic cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Organelle-specific hydrogen sulfide metabolism governs redox homeostasis to regulate plant autophagy and cadmium stress resilience.Redox biology · 2026Article
- Development of a cost-effective medium for enhanced biomass-associated fucoxanthin and bio-silica yields of diatom (Melosira nummuloides).Journal of microbiology (Seoul, Korea) · 2026Article
- Evolutionary conservation and metabolic significance of autophagy in algae.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Studying plant autophagy: challenges and recommended methodologies.Advanced biotechnology · 2023Review
- Palmelloid Formation and Cell Aggregation Are Essential Mechanisms for High Light Tolerance in a Natural Strain ofInternational journal of molecular sciences · 2023Article
- Algal Autophagy Is Necessary for the Regulation of Carbon Metabolism Under Nutrient Deficiency.Frontiers in plant science · 2020Review
- When Unity Is Strength: The Strategies Used byCells · 2019Review
- Article
- A Series of Fortunate Events: Introducing Chlamydomonas as a Reference Organism.The Plant cell · 2019Review
- Chloroplast Damage Induced by the Inhibition of Fatty Acid Synthesis Triggers Autophagy in Chlamydomonas.Plant physiology · 2018Article
- Understanding and exploiting the roles of autophagy in plants through multi-omics approaches.Plant science : an international journal of experimental plant biology · 2018Review
- Autophagic flux is required for the synthesis of triacylglycerols and ribosomal protein turnover in Chlamydomonas.Journal of experimental botany · 2018Article
- Review
- Responses of Plant Proteins to Heavy Metal Stress-A Review.Frontiers in plant science · 2017Review
- Control of Autophagy in Chlamydomonas Is Mediated through Redox-Dependent Inactivation of the ATG4 Protease.Plant physiology · 2016Article
- Ni induces the CRR1-dependent regulon revealing overlap and distinction between hypoxia and Cu deficiency responses in Chlamydomonas reinhardtii.Metallomics : integrated biometal science · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Autophagy is an intracellular self-degradation pathway by which eukaryotic cells recycle their own material in response to specific stress conditions. Exposure to high concentrations of metals causes cell damage, although the effect of metal stress on autophagy has not been explored in photosynthetic organisms. In this study, we investigated the effect of metal excess on autophagy in the model unicellular green alga Chlamydomonas reinhardtii. We show in cells treated with nickel an upregulation of ATG8 that is independent of CRR1, a global regulator of copper signaling in Chlamydomonas. A similar effect on ATG8 was observed with copper and cobalt but not with cadmium or mercury ions. Transcriptome sequencing data revealed an increase in the abundance of the protein degradation machinery, including that responsible for autophagy, and a substantial overlap of that increased abundance with the hydrogen peroxide response in cells treated with nickel ions. Thus, our results indicate that metal stress triggers autophagy in Chlamydomonas and suggest that excess nickel may cause oxidative damage, which in turn activates degradative pathways, including autophagy, to clear impaired components and recover cellular homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.