ArticleApplied and environmental microbiology2015
Unusual Biosynthesis and Structure of Locillomycins from Bacillus subtilis 916.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
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- Genomic characterization ofFrontiers in microbiology · 2026Article
- A three-plasmid-containing CRISPR-Cas9 platform to engineerApplied and environmental microbiology · 2025Article
- Comprehensive genomic analysis reveals virulence and antibiotic resistance genes in a multidrug-resistant Bacillus cereus isolated from hospital wastewater in Bangladesh.Scientific reports · 2025Article
- Antimicrobial Activity ofInternational journal of molecular sciences · 2025Review
- Prospection for potential new non-ribosomal peptide gene clusters inFrontiers in microbiology · 2025Article
- Discovery and characterization of novel lipopeptides produced by3 Biotech · 2024Article
- Microbial lipopeptides: their pharmaceutical and biotechnological potential, applications, and way forward.World journal of microbiology & biotechnology · 2024Review
- A Family of Antibiotics That Evades Resistance by Binding Polyprenyl Phosphates.ACS infectious diseases · 2023Article
- Genome mining conformance to metabolite profile of Bacillus strains to control potato pathogens.Scientific reports · 2023Article
- Plant-Associated Representatives of theMicroorganisms · 2023Article
- Lichenysin-like Polypeptide Production byMicroorganisms · 2023Article
- Biosynthesis of Antifungal Solanimycin May Involve an Iterative Nonribosomal Peptide Synthetase Module.ACS chemical biology · 2023Article
- Genome Sequencing and Genetic Engineering Reveal the Contribution of Bacitracin Produced by Bacillus paralicheniformis CPL618 to Anti-Staphylococcus aureus Activity.Current microbiology · 2023Article
- Classification and Multifaceted Potential of Secondary Metabolites Produced byMolecules (Basel, Switzerland) · 2023Review
- Bacteria Halotolerant from Karst Sinkholes as a Source of Biosurfactants and Bioemulsifiers.Microorganisms · 2022Article
- Molecular characterization of a novel strain ofFrontiers in plant science · 2022Article
- Bacillus sp.: A Remarkable Source of Bioactive Lipopeptides.Advances in biochemical engineering/biotechnology · 2022Article
- Exploring the Nature of the Antimicrobial Metabolites Produced byAntibiotics (Basel, Switzerland) · 2021Article
- Potential of Bacillus velezensis as a probiotic in animal feed: a review.Journal of microbiology (Seoul, Korea) · 2021Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three families of Bacillus cyclic lipopeptides--surfactins, iturins, and fengycins--have well-recognized potential uses in biotechnology and biopharmaceutical applications. This study outlines the isolation and characterization of locillomycins, a novel family of cyclic lipopeptides produced by Bacillus subtilis 916. Elucidation of the locillomycin structure revealed several molecular features not observed in other Bacillus lipopeptides, including a unique nonapeptide sequence and macrocyclization. Locillomycins are active against bacteria and viruses. Biochemical analysis and gene deletion studies have supported the assignment of a 38-kb gene cluster as the locillomycin biosynthetic gene cluster. Interestingly, this gene cluster encodes 4 proteins (LocA, LocB, LocC, and LocD) that form a hexamodular nonribosomal peptide synthetase to biosynthesize cyclic nonapeptides. Genome analysis and the chemical structures of the end products indicated that the biosynthetic pathway exhibits two distinct features: (i) a nonlinear hexamodular assembly line, with three modules in the middle utilized twice and the first and last two modules used only once and (ii) several domains that are skipped or optionally selected.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.