ArticleApplied and environmental microbiology2015
Attenuation of Colitis by Lactobacillus casei BL23 Is Dependent on the Dairy Delivery Matrix.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Trial
- Practical Formulation-Associated Immunomodulatory Responses ofMicroorganisms · 2026Article
- Impact of Fermented Dairy on Gastrointestinal Health and Associated Biomarkers.Nutrition reviews · 2026Review
- Genetically Modified Lactic Acid Bacteria: a Promising Mucosal Delivery Vector for Vaccines.Probiotics and antimicrobial proteins · 2026Review
- Polyphenol-modified probiotics for the enhanced survivability, persistence and colonization of probiotic cells in the gut.Current research in food science · 2026Article
- AGut microbiome (Cambridge, England) · 2026Article
- Lactobacilli-Derived Microbe-Associated Molecular Patterns (MAMPs) in Host Immune Modulation.Biomolecules · 2025Review
- The Influence of Different Butter Type, Their Fatty Acid Composition and Melting Enthalpy on the Viability Rate ofFoods (Basel, Switzerland) · 2024Article
- Milk andAmerican journal of physiology. Gastrointestinal and liver physiology · 2024Article
- The effects of dairy on the gut microbiome and symptoms in gastrointestinal disease cohorts: a systematic review.Gut microbiome (Cambridge, England) · 2024Review
- Draft Genome Sequence and Comparative Genome Analysis Reveal Potential Functional Properties in Lacticaseibacillus paracasei ItalPN16.Current microbiology · 2023Article
- Cell-Free Supernatant Derived from aBiomedicines · 2023Article
- Factors Affecting Spontaneous Endocytosis and Survival of Probiotic Lactobacilli in Human Intestinal Epithelial Cells.Microorganisms · 2022Article
- Comparison Between Different Delivery Vehicles for the Probiotic Bifidobacterium animalis subsp. lactis HN019 on Experimental Periodontitis in Rats.Probiotics and antimicrobial proteins · 2022Article
- Next-Generation Probiotics: Microflora Intervention to Human Diseases.BioMed research international · 2022Review
- Role of milk and honey in the tolerance of lactobacilli to oxidative stress.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- The Administration Matrix Modifies the Beneficial Properties of a Probiotic Mix of Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus acidophilus LA-5.Probiotics and antimicrobial proteins · 2021Article
- The Role of Vasoactive Intestinal Peptide and Mast Cells in the Regulatory Effect ofFrontiers in immunology · 2021Article
- Fermentation revival in the classroom: investigating ancient human practices as CUREs for modern diseases.FEMS microbiology letters · 2020Article
- Lactobacillus casei extracellular vesicles stimulate EGFR pathway likely due to the presence of proteins P40 and P75 bound to their surface.Scientific reports · 2020Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the food delivery matrix in probiotic performance in the intestine is not well understood. Because probiotics are often provided to consumers in dairy products, we investigated the contributions of milk to the health-benefiting performance of Lactobacillus casei BL23 in a dextran sulfate sodium (DSS)-induced murine model of ulcerative colitis. L. casei BL23 protected against the development of colitis when ingested in milk but not in a nutrient-free buffer simulating consumption as a nutritional supplement. Consumption of (acidified) milk alone also provided some protection against weight loss and intestinal inflammation but was not as effective as L. casei and milk in combination. In contrast, L. casei mutants deficient in DltD (lipoteichoic acid d-alanine transfer protein) or RecA (recombinase A) were unable to protect against DSS-induced colitis, even when consumed in the presence of milk. Mice fed either L. casei or milk contained reduced quantities of colonic proinflammatory cytokines, indicating that the L. casei DltD(-) and RecA(-) mutants as well as L. casei BL23 in nutrient-free buffer were effective at modulating immune responses. However, there was not a direct correlation between colitis and quantities of these cytokines at the time of sacrifice. Identification of the cecal microbiota by 16S rRNA gene sequencing showed that L. casei in milk enriched for Comamonadaceae and Bifidobacteriaceae; however, the consumption of neither L. casei nor milk resulted in the restoration of the microbiota to resemble that of healthy animals. These findings strongly indicate that probiotic strain efficacy can be influenced by the food/supplement delivery matrix.
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