Evidence map›Paper›PMID 26162863›Full record

ArticleMolecular pharmacology2015

Exploring the Biology of G Protein-Coupled Receptors from In Vitro to In Vivo.

Laura M Bohn, Martin J Lohse, Michael N Nitabach, Paul H Taghert, Martine J Smit

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. New Technologies for Elucidating Opioid Receptor Function.Trends in pharmacological sciences · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Laura M BohnThe Scripps Research Institute, Jupiter, Florida (L.M.B.), University of Würzburg, Würzburg, Germany (M.J.L.); Yale University, New Haven, Connecticut (M.N.N.); Washington University Medical School, St. Louis, Missouri (P.H.T.); and VU University Amsterdam, Amsterdam, The Netherlands (M.J.S.).
Martin J LohseThe Scripps Research Institute, Jupiter, Florida (L.M.B.), University of Würzburg, Würzburg, Germany (M.J.L.); Yale University, New Haven, Connecticut (M.N.N.); Washington University Medical School, St. Louis, Missouri (P.H.T.); and VU University Amsterdam, Amsterdam, The Netherlands (M.J.S.).
Michael N NitabachThe Scripps Research Institute, Jupiter, Florida (L.M.B.), University of Würzburg, Würzburg, Germany (M.J.L.); Yale University, New Haven, Connecticut (M.N.N.); Washington University Medical School, St. Louis, Missouri (P.H.T.); and VU University Amsterdam, Amsterdam, The Netherlands (M.J.S.).
Paul H TaghertThe Scripps Research Institute, Jupiter, Florida (L.M.B.), University of Würzburg, Würzburg, Germany (M.J.L.); Yale University, New Haven, Connecticut (M.N.N.); Washington University Medical School, St. Louis, Missouri (P.H.T.); and VU University Amsterdam, Amsterdam, The Netherlands (M.J.S.).
Martine J SmitThe Scripps Research Institute, Jupiter, Florida (L.M.B.), University of Würzburg, Würzburg, Germany (M.J.L.); Yale University, New Haven, Connecticut (M.N.N.); Washington University Medical School, St. Louis, Missouri (P.H.T.); and VU University Amsterdam, Amsterdam, The Netherlands (M.J.S.).

Funding

MECHANISMS OF CIRCADIAN CLOCK OUTPUTR01MH067122 · NIMH · WASHINGTON UNIVERSITY · PI TAGHERT, PAUL H · 2003 to 2017
$5.7M
DEVELOPMENTAL REGULATION OF NEUROPEPTIDE EXPRESSIONR01NS021749 · NINDS · WASHINGTON UNIVERSITY · PI TAGHERT, PAUL H · 1985 to 2013
$4.3M
NIMH NIH HHS R01 MH067122NINDS NIH HHS R01 NS021749
6 · The paper itself

Abstract

In August 2014, an international group of researchers gathered for 5 days at the Lorentz Center in Leiden, The Netherlands, to explore the technical and conceptual issues associated with the analysis of G protein-coupled receptor functions utilizing information from crystal structure models to the use of model organisms. This collection of review articles evolved from the 5-day meeting, with brief presentations and structured discussion periods that were designed to identify key questions remaining in understanding G protein-coupled receptor function and to propose novel strategies by integrating scientific disciplines to guide future research.

Indexed as

Congresses as TopicAnimalsHumansReceptors, G-Protein-CoupledReceptors, G-Protein-Coupled

Identifiers

PMID26162863
PMCPMC13174925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.