ArticlePlacenta2015
Placental expression of imprinted genes varies with sampling site and mode of delivery.
Article in Placenta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Up-regulated mRNA expression of VEGFA receptors (FLT1 and KDR) in placentas after assisted reproductive technology fertilization.Journal of applied genetics · 2024Article
- Placental ferroportin protein abundance is associated with neonatal erythropoietic activity and iron status in newborns at high risk for iron deficiency and anemia.The American journal of clinical nutrition · 2024Article
- The influence of early environment and micronutrient availability on developmental epigenetic programming: lessons from the placenta.Frontiers in cell and developmental biology · 2023Review
- Review
- Placental expression of miR-21-5p, miR-210-3p and miR-141-3p: relation to human fetoplacental growth.European journal of clinical nutrition · 2022Article
- Functional Analysis of p21Cells · 2021Article
- DNA Methylation and Recurrent Pregnancy Loss: A Mysterious Compass?Frontiers in immunology · 2021Review
- Differences in expression rather than methylation at placenta-specific imprinted loci is associated with intrauterine growth restriction.Clinical epigenetics · 2019Article
- Metformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes.PloS one · 2018Article
- Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis.Placenta · 2017Article
- Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes.Archives of gynecology and obstetrics · 2017Review
- Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3.Psychological medicine · 2016Article
- Placental PHLDA2 expression is increased in cases of fetal growth restriction following reduced fetal movements.BMC medical genetics · 2016Article
- Article
- Race-specific Association of Caesarean-Section Delivery with Body Size at Age 2 Years.Ethnicity & disease · 2016Article
- Epigenetic Characterization of CDKN1C in Placenta Samples from Non-syndromic Intrauterine Growth Restriction.Frontiers in genetics · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledImprinted genes, which are monoallelically expressed by virtue of an epigenetic process initiated in the germline, are known to play key roles in regulating fetal growth and placental development. Numerous studies are investigating the expression of these imprinted genes in the human placenta in relation to common complications of pregnancy such as fetal growth restriction and preeclampsia. This study aimed to determine whether placental sampling protocols or other factors such as fetal sex, gestational age and mode of delivery may influence the expression of imprinted genes predicted to regulate placental signalling.
methodsTerm placentas were collected from Caucasian women delivering at University Hospital of Wales or Royal Gwent Hospital within two hours of delivery. Expression of the imprinted genes PHLDA2, CDKN1C, PEG3 and PEG10 was assayed by quantitative real time PCR. Intraplacental gene expression was analysed (N = 5). Placental gene expression was compared between male (N = 11) and female (N = 11) infants, early term (N = 8) and late term (N = 10) deliveries and between labouring (N = 13) and non-labouring (N = 21) participants.
resultsThe paternally expressed imprinted genes PEG3 and PEG10 were resilient to differences in sampling site, fetal sex, term gestational age and mode of delivery. The maternally expressed imprinted gene CDKN1C was elevated over 2-fold (p < 0.001) in placenta from labouring deliveries compared with elective caesarean sections. In addition, the maternally expressed imprinted gene PHLDA2 was elevated by 1.8 fold (p = 0.01) in samples taken at the distal edge of the placenta compared to the cord insertion site.
conclusionThese findings support the reinterpretation of existing data sets on these genes in relation to complications of pregnancy and further reinforce the importance of optimising and unifying placental collection protocols for future studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.