Evidence map›Paper›PMID 26162656›Full record

ArticlePsychiatry research2015

Lateralization for speech predicts therapeutic response to cognitive behavioral therapy for depression.

Ronit Kishon, Karen Abraham, Daniel M Alschuler, John G Keilp, Jonathan W Stewart, Patrick J McGrath, Gerard E Bruder

Abstract read
In one paragraph

Article in Psychiatry research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ronit KishonDepression Evaluation Service, New York State Psychiatric Institute, USA; Department of Psychiatry, Columbia University College of Physicians & Surgeons, USA.
Karen AbrahamDivision of Cognitive Neuroscience, New York State Psychiatric Institute, USA.
Daniel M AlschulerDivision of Cognitive Neuroscience, New York State Psychiatric Institute, USA.
John G KeilpDepartment of Psychiatry, Columbia University College of Physicians & Surgeons, USA; Division of Molecular Imaging & Neuropathology, New York State Psychiatric Institute, USA.
Jonathan W StewartDepression Evaluation Service, New York State Psychiatric Institute, USA; Department of Psychiatry, Columbia University College of Physicians & Surgeons, USA.
Patrick J McGrathDepression Evaluation Service, New York State Psychiatric Institute, USA; Department of Psychiatry, Columbia University College of Physicians & Surgeons, USA.
Gerard E BruderDepartment of Psychiatry, Columbia University College of Physicians & Surgeons, USA; Division of Cognitive Neuroscience, New York State Psychiatric Institute, USA. Electronic address: bruderg@nyspi.columbia.edu.

Funding

BEHAVIORAL, ERP AND RCBF ASYMMETRY IN AFFECTIVE DISORDERR01MH036295 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BRUDER, GERARD E · 1985 to 2012
$3.7M
NIMH NIH HHS MH36295NIMH NIH HHS R01 MH036295
6 · The paper itself

Abstract

A prior study (Bruder, G.E., Stewart, J.W., Mercier, M.A., Agosti, V., Leite, P., Donovan, S., Quitkin, F.M., 1997. Outcome of cognitive-behavioral therapy for depression: relation of hemispheric dominance for verbal processing. Journal of Abnormal Psychology 106, 138-144.) found left hemisphere advantage for verbal dichotic listening was predictive of clinical response to cognitive behavioral therapy (CBT) for depression. This study aimed to confirm this finding and to examine the value of neuropsychological tests, which have shown promise for predicting antidepressant response. Twenty depressed patients who subsequently completed 14 weeks of CBT and 74 healthy adults were tested on a Dichotic Fused Words Test (DFWT). Patients were also tested on the National Adult Reading Test to estimate IQ, and word fluency, choice RT, and Stroop neuropsychological tests. Left hemisphere advantage on the DFWT was more than twice as large in CBT responders as in non-responders, and was associated with improvement in depression following treatment. There was no difference between responders and non-responders on neuropsychological tests. The results support the hypothesis that the ability of individuals with strong left hemisphere dominance to recruit frontal and temporal cortical regions involved in verbal dichotic listening predicts CBT response. The large effect size, sensitivity and specificity of DFWT predictions suggest the potential value of this brief and inexpensive test as an indicator of whether a patient will benefit from CBT for depression.

Indexed as

Cognitive Behavioral TherapyDominance, CerebralSpeech PerceptionAdultAgedDichotic Listening TestsFemaleHumansMajor Depressive DisorderMaleMiddle AgedNeuropsychological TestsTreatment OutcomeYoung AdultCBTDepressionDichotic listeningLateralizationNeuropsychological tests

Identifiers

PMID26162656
PMCPMC4532556

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.