ArticleActa biomaterialia2015
Elastin governs the mechanical response of medial collateral ligament under shear and transverse tensile loading.
Article in Acta biomaterialia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Integrated Analysis of Rat Pulmonary Hypertension Datasets Identifies Candidate circRNA Networks in Hypoxia-Exposed Pulmonary Artery Tissue.International journal of molecular sciences · 2026Article
- Understanding Anterior Cruciate Ligament Adaptation: Structural, Mechanical, and Healing Considerations.Sports medicine (Auckland, N.Z.) · 2026Review
- Development and validation of a novel approach for quantifying dimensions of the lateral ligaments in human ankle dissections.Journal of anatomy · 2026Article
- Collagen-elastin microstructural network and its mechanical implications in the anterior cruciate ligament: A feasibility study.Journal of orthopaedic surgery and research · 2026Article
- Review
- Impact of aging and estrogen deficiency on extracellular matrix-related gene expression in rotator cuff tendons: in vitro and in vivo rat model.JSES international · 2025Article
- An algorithmic and software framework to incorporate orientation distribution functions in finite element simulations for biomechanics and biophysics.Acta biomaterialia · 2025Article
- The alteration of the structure and macroscopic mechanical response of porcine patellar tendon by elastase digestion.Frontiers in bioengineering and biotechnology · 2024Article
- Contribution of Elastic and Collagen Fibers to the Mechanical Behavior of Bovine Nuchal Ligament.Annals of biomedical engineering · 2023Article
- Biomechanical Properties of Knee Medial Collateral Ligament Compared to Palmaris Longus for Ulnar Collateral Ligament Reconstruction.Annals of biomedical engineering · 2023Article
- Role of elastic fiber degradation in disease pathogenesis.Biochimica et biophysica acta. Molecular basis of disease · 2023Review
- Time-dependent extracellular matrix alterations of young tendons in response to stress relaxation: a model for the Ponseti method.Journal of the Royal Society, Interface · 2023Article
- Elastin is responsible for the rigidity of the ligament under shear and rotational stress: a mathematical simulation study.Journal of orthopaedic surgery and research · 2023Article
- Adaptation of Fibril-Reinforced Poroviscoelastic Properties in Rabbit Collateral Ligaments 8 Weeks After Anterior Cruciate Ligament Transection.Annals of biomedical engineering · 2023Article
- Three-dimensional mechanical characterization of murine skeletal muscle using quantitative micro-elastography.Biomedical optics express · 2022Article
- The anterior cruciate ligament in murine post-traumatic osteoarthritis: markers and mechanics.Arthritis research & therapy · 2022Article
- The Role of the Non-Collagenous Extracellular Matrix in Tendon and Ligament Mechanical Behavior: A Review.Journal of biomechanical engineering · 2022Review
- Near infrared spectroscopic evaluation of biochemical and crimp properties of knee joint ligaments and patellar tendon.PloS one · 2022Article
- Tissue-specific parameters for the design of ECM-mimetic biomaterials.Acta biomaterialia · 2021Review
- Through-thickness regional variation in the mechanical characteristics of the lumbar facet capsular ligament.Biomechanics and modeling in mechanobiology · 2021Article
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Authors and funding
4 authors.
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Abstract
Elastin is a highly extensible structural protein network that provides near-elastic resistance to deformation in biological tissues. In ligament, elastin is localized between and along the collagen fibers and fascicles. When ligament is stretched along the primary collagen axis, elastin supports a relatively high percentage of load. We hypothesized that elastin may also provide significant load support under elongation transverse to the primary collagen axis and shear along the collagen axis. Quasi-static transverse tensile and shear material tests were performed to quantify the mechanical contributions of elastin during deformation of porcine medial collateral ligament. Dose response studies were conducted to determine the level of elastase enzymatic degradation required to produce a maximal change in the mechanical response. Maximal changes in peak stress occurred after 3h of treatment with 2U/ml porcine pancreatic elastase. Elastin degradation resulted in a 60-70% reduction in peak stress and a 2-3× reduction in modulus for both test protocols. These results demonstrate that elastin provides significant resistance to elongation transverse to the collagen axis and shear along the collagen axis while only constituting 4% of the tissue dry weight. The magnitudes of the elastin contribution to peak transverse and shear stress were approximately 0.03 MPa, as compared to 2 MPa for axial tensile tests, suggesting that elastin provides a highly anisotropic contribution to the mechanical response of ligament and is the dominant structural protein resisting transverse and shear deformation of the tissue.
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