Evidence map›Paper›PMID 26162576›Full record

ArticleEuropean radiology2016

Feasibility of measuring renal blood flow by phase-contrast magnetic resonance imaging in patients with autosomal dominant polycystic kidney disease.

E M Spithoven, E Meijer, C Borns, W E Boertien, C A J M Gaillard, P Kappert, M J W Greuter, E van der Jagt, P Vart, P E de Jong and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Renal blood flow and progression to kidney failure in ADPKD.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Observational
  3. Review
  4. Review
  5. Review
  6. BOLD magnetic resonance imaging in nephrology.International journal of nephrology and renovascular disease · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

E M SpithovenDepartment of Nephrology, Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700, RB Groningen, The Netherlands.
E MeijerDepartment of Nephrology, Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700, RB Groningen, The Netherlands.
C BornsDepartment of Radiology, Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
W E BoertienDepartment of Nephrology, Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700, RB Groningen, The Netherlands.
C A J M GaillardDepartment of Nephrology, Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700, RB Groningen, The Netherlands.
P KappertDepartment of Radiology, Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
M J W GreuterDepartment of Radiology, Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
E van der JagtDepartment of Radiology, Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
P VartDepartment of Health Sciences, Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
P E de JongDepartment of Nephrology, Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700, RB Groningen, The Netherlands.
R T GansevoortDepartment of Nephrology, Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700, RB Groningen, The Netherlands. R.T.Gansevoort@umcg.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesRenal blood flow (RBF) has been shown to predict disease progression in autosomal dominant polycystic kidney disease (ADPKD). We investigated the feasibility and accuracy of phase-contrast RBF by MRI (RBFMRI) in ADPKD patients with a wide range of estimated glomerular filtration rate (eGFR) values.

methodsFirst, we validated RBFMRI measurement using phantoms simulating renal artery hemodynamics. Thereafter, we investigated in a test-set of 21 patients intra- and inter-observer coefficient of variation of RBFMRI. After validation, we measured RBFMRI in a cohort of 91 patients and compared the variability explained by characteristics indicative for disease severity for RBFMRI and RBF measured by continuous hippuran infusion.

resultsThe correlation in flow measurement using phantoms by phase-contrast MRI was high and fluid collection was high (CCC=0.969). Technical problems that precluded RBFMRI measurement occurred predominantly in patients with a lower eGFR (34% vs. 16%). In subjects with higher eGFRs, variability in RBF explained by disease characteristics was similar for RBFMRI compared to RBFHip, whereas in subjects with lower eGFRs, this was significantly less for RBFMRI.

conclusionsOur study shows that RBF can be measured accurately in ADPKD patients by phase-contrast, but this technique may be less feasible in subjects with a lower eGFR. KEY POINTS: Renal blood flow (RBF) can be accurately measured by phase-contrast MRI in ADPKD patients. RBF measured by phase-contrast is associated with ADPKD disease severity. RBF measurement by phase-contrast MRI may be less feasible in patients with an impaired eGFR.

Indexed as

AdultBlood PressureCohort StudiesContrast MediaDisease ProgressionFeasibility StudiesFemaleGlomerular Filtration RateHemodynamicsHumansIodine RadioisotopesIodohippuric AcidMagnetic Resonance ImagingMaleMiddle AgedPhantoms, ImagingContrast MediaIodine RadioisotopesIodohippuric AcidRadiopharmaceuticalsADPKDHippuranPhantomPhase-contrast MRIRenal blood flow measurement

Identifiers

PMID26162576
PMCPMC4748006

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.