Evidence map›Paper›PMID 26162533›Full record

ArticleMolecular diversity2015

Synthesis and antiproliferative activity of pterostilbene and 3′-methoxy pterostilbene Mannich base derivatives against Hela cells.

Chongyang Liu, Linpei Dong, Shengchun Wang, Qiuan Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular diversity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chongyang LiuCollege of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China.
Linpei DongCollege of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China.
Shengchun WangCollege of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China.
Qiuan WangCollege of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China. wangqa@hnu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fourteen novel pterostilbene (1) and [Formula: see text]-methoxy pterostilbene (2) Mannich base derivatives (3-16) were synthesized via the microwave-assisted Mannich reaction of 1 or 2 with various secondary amines and formaldehyde. The regioselectivity of the reaction occurred preferentially at [Formula: see text] position of the B-ring of stilbene. The biological testing results showed that all the target compounds exhibit antiproliferative activity against Hela cells from [Formula: see text]-[Formula: see text]. Compounds 1-3, 7, 11-13, and 16 displayed higher (lower [Formula: see text] values) activity than the positive control cisplatin [Formula: see text].

Indexed as

Antineoplastic AgentsCell ProliferationHeLa CellsHumansMannich BasesMolecular StructureStilbenesAntineoplastic AgentsMannich BasespterostilbeneStilbenesAntiproliferative activityHela cellsMannich base derivatives-Methoxy pterostilbenePterostilbeneSynthesis

Identifiers

PMID26162533
PMCPMC4591201

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.