ArticleGenome biology2015
The nature of evidence for and against epigenetic inheritance.
Article in Genome biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Article
- Paternal diet induces transgenerational epigenetic inheritance of DNA methylation signatures and phenotypes in sheep model.PNAS nexus · 2022Article
- Non-genetic inheritance via the male germline in mammals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Investigation into the role of the germline epigenome in the transmission of glucocorticoid-programmed effects across generations.Genome biology · 2018Article
- Review: DNA methylation and alcohol use disorders: Progress and challenges.The American journal on addictions · 2017Review
- High type II error and interpretation inconsistencies when attempting to refute transgenerational epigenetic inheritance.Genome biology · 2016Article
- Dexamethasone treatment alters insulin, leptin, and adiponectin levels in male mice as observed in DIO but does not lead to alterations of metabolic phenotypes in the offspring.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Not so fast. The Iqbal et. al. study and the associated Whitelaw commentary highlight the appropriately high standards of study design and interpretation needed to obtain good evidence for or against epigenetic inheritance. Please see related article: www.dx.doi.org/10.1186/s13059-015-0714-1.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.