SynthesisMolecular neurobiology2016
Chromosome 4q25 Variants rs2200733, rs10033464, and rs1906591 Contribute to Ischemic Stroke Risk.
Synthesis in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Genotype-phenotype associations in atrial fibrillation: meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2019Pooled it
- Genetic variants and polygenic risk scores associated with paroxysmal atrial fibrillation in the Japanese population.PloS one · 2026Article
- Prevalence of Genetic Variants Associated with Atrial Fibrillation Risk in the Asymptomatic Young Adult Population.Medicina (Kaunas, Lithuania) · 2025Article
- Association Between rs2200733 Polymorphism of PITX2 Gene and the Risk of Atrial Fibrillation.Anatolian journal of cardiology · 2023Article
- Chromosome 4q25 Variants and Age at Onset of Ischemic Stroke.Molecular neurobiology · 2017Article
- Association Between a Polymorphism (rs2071214) in Baculoviral IAP Repeat Containing 5 Gene (BIRC5) and Ischemic Stroke in Korean Population.Annals of rehabilitation medicine · 2016Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown an association between chromosome 4q25 variants (rs2200733, rs10033464, and rs1906591) and the risk of ischemic stroke. However, the results are inconsistent. Thus, we conducted this meta-analysis to evaluate risk effect of chromosome 4q25 variants on ischemic stroke. We performed the literature search in PubMed and Embase through October 2014 for all the potentially relevant studies. The odds ratios (ORs), together with the corresponding 95 % confidence intervals (95 % CIs) were calculated to evaluate the strength of association. The search yielded eight studies (13 reports for rs2200733, 13 reports for rs10033464, and 7 reports for rs1906591). The ORs for overall ischemic stroke risk were 1.17 (95 % CI 1.09-1.26) for rs2200733*T, 1.02 (95 % CI 0.96-1.08) for rs10033464*T and 1.21 (95 % CI 1.10-1.32) for rs1906591*A. Stratified analysis by ischemic stroke subtypes revealed a stronger association between all the variants and cardioembolic stroke (CES) (OR = 1.41, 95 % CI 1.31-1.53 for rs2200733*T, OR = 1.18, 95 % CI 1.07-1.31 for rs10033464*T and OR = 1.51, 95 % CI 1.29-1.77 for rs1906591*A). The results of our meta-analysis indicated that chromosome 4q25 variants are associated with ischemic stroke risk, in particular cardioembolic stroke (CES).
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