Evidence map›Paper›PMID 26162094›Full record

ArticlePLoS neglected tropical diseases2015

Efficacy of Recombinant Canine Distemper Virus Expressing Leishmania Antigen against Leishmania Challenge in Dogs.

Ryuichi Miura, Takanori Kooriyama, Misako Yoneda, Akiko Takenaka, Miho Doki, Yasuyuki Goto, Chizu Sanjoba, Yasuyuki Endo, Tomoko Fujiyuki, Akihiro Sugai and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. An update on recombinant vaccines against leishmaniasis.The Indian journal of medical research · 2024
    Review
  2. Article
  3. Article
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  5. Stage-Specific Class I Nucleases ofFrontiers in cellular and infection microbiology · 2021
    Review
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Ryuichi MiuraLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Takanori KooriyamaLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Misako YonedaLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Akiko TakenakaLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Miho DokiLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Yasuyuki GotoDepartment of Molecular Immunology, School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan.
Chizu SanjobaDepartment of Molecular Immunology, School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan.
Yasuyuki EndoLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Tomoko FujiyukiLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Akihiro SugaiLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Kyoko Tsukiyama-KoharaJoint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Yoshitsugu MatsumotoDepartment of Molecular Immunology, School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan.
Hiroki SatoLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Chieko KaiLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPKagoshima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Canine distemper virus (CDV) vaccination confers long-term protection against CDV reinfection. To investigate the utility of CDV as a polyvalent vaccine vector for Leishmania, we generated recombinant CDVs, based on an avirulent Yanaka strain, that expressed Leishmania antigens: LACK, TSA, or LmSTI1 (rCDV-LACK, rCDV-TSA, and rCDV-LmSTI1, respectively). Dogs immunized with rCDV-LACK were protected against challenge with lethal doses of virulent CDV, in the same way as the parental Yanaka strain. To evaluate the protective effects of the recombinant CDVs against cutaneous leishmaniasis in dogs, dogs were immunized with one recombinant CDV or a cocktail of three recombinant CDVs, before intradermal challenge (in the ears) with infective-stage promastigotes of Leishmania major. Unvaccinated dogs showed increased nodules with ulcer formation after 3 weeks, whereas dogs immunized with rCDV-LACK showed markedly smaller nodules without ulceration. Although the rCDV-TSA- and rCDV-LmSTI1-immunized dogs showed little protection against L. major, the cocktail of three recombinant CDVs more effectively suppressed the progression of nodule formation than immunization with rCDV-LACK alone. These results indicate that recombinant CDV is suitable for use as a polyvalent live attenuated vaccine for protection against both CDV and L. major infections in dogs.

Indexed as

AnimalsAntibodies, ViralAntigens, ProtozoanDistemper Virus, CanineDogsFemaleGenetic VectorsHumansLeishmania majorLeishmaniasis, CutaneousProtozoan VaccinesViral VaccinesAntibodies, ViralAntigens, ProtozoanProtozoan VaccinesViral Vaccines

Identifiers

PMID26162094
PMCPMC4498809
OpenAlexW881350307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.