Evidence map›Paper›PMID 26162026›Full record

ArticleRadiology2016

Hepatic MR Elastography: Clinical Performance in a Series of 1377 Consecutive Examinations.

Meng Yin, Kevin J Glaser, Jayant A Talwalkar, Jun Chen, Armando Manduca, Richard L Ehman

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06916715 (Feasibility and Diagnostic Accuracy of Magnetic Resonance Elastography in Intracranial Space-Occupying Lesions), which is not on this map. Cited by 129 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 5 pooled it
19.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06916715 active not recruitingnot on this mapstarted 2017, after this paper: background citation

Feasibility and Diagnostic Accuracy of Magnetic Resonance Elastography in Intracranial Space-Occupying Lesions

TypeobservationalSponsorShengjing HospitalRan2017 to 2026Enrolled626ConditionsBrain Neoplasms
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 5 syntheses or guidelines pooled it, 265 citations in OpenAlex.

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  5. Magnetic Resonance vs Transient Elastography Analysis of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Pooled Analysis of Individual Participants.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2019
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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Meng YinFrom the Departments of Radiology (M.Y., K.J.G., J.C., A.M., R.L.E.) and Gastroenterology (J.A.T.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Kevin J GlaserFrom the Departments of Radiology (M.Y., K.J.G., J.C., A.M., R.L.E.) and Gastroenterology (J.A.T.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Jayant A TalwalkarFrom the Departments of Radiology (M.Y., K.J.G., J.C., A.M., R.L.E.) and Gastroenterology (J.A.T.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Jun ChenFrom the Departments of Radiology (M.Y., K.J.G., J.C., A.M., R.L.E.) and Gastroenterology (J.A.T.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Armando ManducaFrom the Departments of Radiology (M.Y., K.J.G., J.C., A.M., R.L.E.) and Gastroenterology (J.A.T.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Richard L EhmanFrom the Departments of Radiology (M.Y., K.J.G., J.C., A.M., R.L.E.) and Gastroenterology (J.A.T.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Mayo Clinic · US

Funding

Comprehensive noninvasive assessment of liver histopathology in nonalcoholic fatty liver disease (NAFLD) via magnetic resonance imaging, cytometry and elastography (MR-ICE)R01EB017197 · NIBIB · MAYO CLINIC ROCHESTER · PI YIN, MENG · 2014 to 2025
$4.3M
Magnetic Resonance ElastographyR37EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2016 to 2025
$4.0M
Magnetic Resonance ElastographyR01EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2003 to 2013
$3.1M
NIBIB NIH HHS R01 EB001981NIBIB NIH HHS R01 EB017197NIBIB NIH HHS R37 EB001981
6 · The paper itself

Abstract

purposeTo assess the technical success rate and diagnostic performance of liver magnetic resonance (MR) elastography. MATERIALS AND

methodsThis retrospective study was approved by the institutional review board with patient informed consent. A total of 1377 consecutive MR elastography examinations performed between 2007 and 2010 in 1287 patients for clinical indications were included. Medical records were used to retrieve liver stiffness as assessed with MR elastography, histologic analysis, blood work, and other liver disease-related information. Nonparametric Kruskal-Wallis tests and analysis of covariance methods were used to evaluate the diagnostic values and relationships of the collected data.

resultsHepatic MR elastography had a success rate of 94.4% (1300 of 1377 cases) and yielded reproducible measurements (r = 0.9716, P < .0001) in the study cohort, with a complex patient profile and multiple interpreters. Body mass index had no significant effect on success rate (P = .2). In 289 patients who underwent liver biopsy within 1 year of the MR elastography date, mean liver stiffness as assessed with MR elastography was significantly higher in patients with advanced fibrosis (stages F3, F4) than in those with mild to moderate fibrosis (stages F0, F1, F2) (5.93 kPa ± 2.31 [standard deviation] vs 3.35 kPa ± 1.44, P < .0001). Liver stiffness is associated with many factors other than fibrosis extent, including cause of fibrosis (viral hepatitis C vs nonalcoholic fatty liver disease, P = .025), inflammation (severe vs mild to moderate, P = .03), and hepatic metabolic and synthetic function (no fibrosis vs intermediate fibrosis, P ≤ .01).

conclusionIn a general clinical practice environment, hepatic MR elastography is a robust imaging method with a high success rate in a broad spectrum of patients. It also shows the complex association between liver stiffness and hepatic pathophysiology.

Indexed as

BiomarkersBiopsyBody Mass IndexElasticity Imaging TechniquesFemaleHumansLiver DiseasesLiver Function TestsMagnetic Resonance ImagingMaleMiddle AgedReproducibility of ResultsRetrospective StudiesSignal-To-Noise RatioBiomarkers

Identifiers

PMID26162026
PMCPMC4688072
OpenAlexW2168493518

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.