ArticleInvestigative ophthalmology & visual science2015
Measurement of Crystalline Lens Volume During Accommodation in a Lens Stretcher.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Age-Related Changes in Lens Elasticity Contribute More to Accommodative Decline Than Shape Change.Investigative ophthalmology & visual science · 2025Article
- On the Cranial Nerves.NeuroSci · 2024Review
- UV light and the ocular lens: a review of exposure models and resulting biomolecular changes.Frontiers in ophthalmology · 2024Review
- Storage-induced mechanical changes of porcine lenses assessed with optical coherence elastography and inverse finite element modeling.Frontiers in bioengineering and biotechnology · 2024Article
- Estimation of the full shape of the crystalline lensBiomedical optics express · 2023Article
- The lens capsule significantly affects the viscoelastic properties of the lens as quantified by optical coherence elastography.Frontiers in bioengineering and biotechnology · 2023Article
- Prediction of Subjective Refraction From Anterior Corneal Surface, Eye Lengths, and Age Using Machine Learning Algorithms.Translational vision science & technology · 2022Article
- Isolated human crystalline lens three-dimensional shape: A comparison between Indian and European populations.Experimental eye research · 2021Article
- Age-Related Changes to the Three-Dimensional Full Shape of the Isolated Human Crystalline Lens.Investigative ophthalmology & visual science · 2020Article
- Lens Stretching Modulates Lens Epithelial Cell Proliferation via YAP Regulation.Investigative ophthalmology & visual science · 2019Article
- The effects of mechanical strain on mouse eye lens capsule and cellular microstructure.Molecular biology of the cell · 2018Article
- Simulating the Mechanics of Lens Accommodation via a Manual Lens Stretcher.Journal of visualized experiments : JoVE · 2018Article
- Simulation and analysis of light scattering by multilamellar bodies present in the human eye.Biomedical optics express · 2017Article
- OCT-based full crystalline lens shape change during accommodation in vivo.Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo determine if the lens volume changes during accommodation.
methodsThe study used data acquired on 36 cynomolgus monkey lenses that were stretched in a stepwise fashion to simulate disaccommodation. At each step, stretching force and dioptric power were measured and a cross-sectional image of the lens was acquired using an optical coherence tomography system. Images were corrected for refractive distortions and lens volume was calculated assuming rotational symmetry. The average change in lens volume was calculated and the relation between volume change and power change, and between volume change and stretching force, were quantified. Linear regressions of volume-power and volume-force plots were calculated.
resultsThe mean (± SD) volume in the unstretched (accommodated) state was 97 ± 8 mm3. On average, there was a small but statistically significant (P = 0.002) increase in measured lens volume with stretching. The mean change in lens volume was +0.8 ± 1.3 mm3. The mean volume-power and volume-load slopes were -0.018 ± 0.058 mm3/D and +0.16 ± 0.40 mm3/g.
conclusionsLens volume remains effectively constant during accommodation, with changes that are less than 1% on average. This result supports a hypothesis that the change in lens shape with accommodation is accompanied by a redistribution of tissue within the capsular bag without significant compression of the lens contents or fluid exchange through the capsule.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.