ArticlePloS one2015
A FDG-PET Study of Metabolic Networks in Apolipoprotein E ε4 Allele Carriers.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- FDG-PET-based brain network analysis: a brief review of metabolic connectivity.EJNMMI reports · 2025Review
- Stable brain PET metabolic networks using a multiple sampling scheme.Network neuroscience (Cambridge, Mass.) · 2025Article
- Lower GLUT1 and unchanged MCT1 in Alzheimer's disease cerebrovasculature.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Review
- Functional brain networks in the evaluation of patients with neurodegenerative disorders.Nature reviews. Neurology · 2023Review
- In Alzheimer-prone brain regions, metabolism and risk-gene expression are strongly correlated.Brain communications · 2022Article
- APOE ε4 and cognitive reserve effects on the functional network in the Alzheimer's disease spectrum.Brain imaging and behavior · 2021Article
- Developmental pattern of the cortical topology in high-functioning individuals with autism spectrum disorder.Human brain mapping · 2021Article
- Apolipoprotein E4 effects on topological brain network organization in mild cognitive impairment.Scientific reports · 2021Article
- Glucose hypometabolism in the Auditory Pathway in Age Related Hearing Loss in the ADNI cohort.NeuroImage. Clinical · 2021Article
- Apolipoprotein E allele 4 effects on Single-Subject Gray Matter Networks in Mild Cognitive Impairment.NeuroImage. Clinical · 2021Article
- Pain-Evoked Reorganization in Functional Brain Networks.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- APOE alters glucose flux through central carbon pathways in astrocytes.Neurobiology of disease · 2020Article
- APOE genotype affects metabolic and Alzheimer-related outcomes induced by Western diet in female EFAD mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- The Influence of Cerebrospinal Fluid Abnormalities and APOE 4 on PHF-Tau Protein: Evidence From Voxel Analysis and Graph Theory.Frontiers in aging neuroscience · 2019Article
- Brain Connectivity Based Prediction of Alzheimer's Disease in Patients With Mild Cognitive Impairment Based on Multi-Modal Images.Frontiers in human neuroscience · 2019Article
- Altered Cerebro-Cerebellar Limbic Network in AD Spectrum: A Resting-State fMRI Study.Frontiers in neural circuits · 2019Article
- Networks of myelin covariance.Human brain mapping · 2018Article
- Learning Metabolic Brain Networks in MCI and AD by Robustness and Leave-One-Out Analysis: An FDG-PET Study.American journal of Alzheimer's disease and other dementias · 2018Article
- Metabolic brain networks in aging and preclinical Alzheimer's disease.NeuroImage. Clinical · 2018Article
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9 authors.
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Abstract
Recently, some studies have applied the graph theory in brain network analysis in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). However, relatively little research has specifically explored the properties of the metabolic network in apolipoprotein E (APOE) ε4 allele carriers. In our study, all the subjects, including ADs, MCIs and NCs (normal controls) were divided into 165 APOE ε4 carriers and 165 APOE ε4 noncarriers. To establish the metabolic network for all brain regions except the cerebellum, cerebral glucose metabolism data obtained from FDG-PET (18F-fluorodeoxyglucose positron emission tomography) were segmented into 90 areas with automated anatomical labeling (AAL) template. Then, the properties of the networks were computed to explore the between-group differences. Our results suggested that both APOE ε4 carriers and noncarriers showed the small-world properties. Besides, compared with APOE ε4 noncarriers, the carriers showed a lower clustering coefficient. In addition, significant changes in 6 hub brain regions were found in between-group nodal centrality. Namely, compared with APOE ε4 noncarriers, significant decreases of the nodal centrality were found in left insula, right insula, right anterior cingulate, right paracingulate gyri, left cuneus, as well as significant increases in left paracentral lobule and left heschl gyrus in APOE ε4 carriers. Increased local short distance interregional correlations and disrupted long distance interregional correlations were found, which may support the point that the APOE ε4 carriers were more similar with AD or MCI in FDG uptake. In summary, the organization of metabolic network in APOE ε4 carriers indicated a less optimal pattern and APOE ε4 might be a risk factor for AD.
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