Evidence map›Paper›PMID 26161791›Full record

ArticleNano letters2015

Dimensionality of Rolled-up Nanomembranes Controls Neural Stem Cell Migration Mechanism.

Britta Koch, Anne K Meyer, Linda Helbig, Stefan M Harazim, Alexander Storch, Samuel Sanchez, Oliver G Schmidt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. An In Vitro System to Study the Mesenchymal-to-Amoeboid Transition.Methods in molecular biology (Clifton, N.J.) · 2018
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Britta Koch†Institute for Integrative Nanosciences, Leibniz Institute for Solid State and Materials Research Dresden, D-01069 Dresden, Germany.
Anne K Meyer†Institute for Integrative Nanosciences, Leibniz Institute for Solid State and Materials Research Dresden, D-01069 Dresden, Germany.
Linda Helbig†Institute for Integrative Nanosciences, Leibniz Institute for Solid State and Materials Research Dresden, D-01069 Dresden, Germany.
Stefan M Harazim†Institute for Integrative Nanosciences, Leibniz Institute for Solid State and Materials Research Dresden, D-01069 Dresden, Germany.
Alexander Storch‡Division of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, D-01307 Dresden, Germany.
Samuel Sanchez†Institute for Integrative Nanosciences, Leibniz Institute for Solid State and Materials Research Dresden, D-01069 Dresden, Germany.
Oliver G Schmidt†Institute for Integrative Nanosciences, Leibniz Institute for Solid State and Materials Research Dresden, D-01069 Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We employ glass microtube structures fabricated by rolled-up nanotechnology to infer the influence of scaffold dimensionality and cell confinement on neural stem cell (NSC) migration. Thereby, we observe a pronounced morphology change that marks a reversible mesenchymal to amoeboid migration mode transition. Space restrictions preset by the diameter of nanomembrane topography modify the cell shape toward characteristics found in living tissue. We demonstrate the importance of substrate dimensionality for the migration mode of NSCs and thereby define rolled-up nanomembranes as the ultimate tool for single-cell migration studies.

Indexed as

Cell MovementAnimalsCell LineGlassMembranes, ArtificialMiceNanostructuresNanotechnologyNeural Stem CellsTissue ScaffoldsMembranes, Artificial3D cell culture scaffoldcell migrationNanomembranesneural stem cellsrolled-up nanotechnologyspatial confinement

Identifiers

PMID26161791
PMCPMC4538455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.