Evidence map›Paper›PMID 26161741›Full record

SynthesisPloS one2015

Effect of Probiotics on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized, Controlled Trials.

Yuting Ruan, Jia Sun, Jie He, Fangyao Chen, Rongping Chen, Hong Chen

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 16 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 16 syntheses or guidelines pooled it, 208 citations in OpenAlex.

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  3. The Role ofInternational journal of molecular sciences · 2024
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  20. Effect of DailyMedicina (Kaunas, Lithuania) · 2025
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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yuting RuanDepartment of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Jia SunDepartment of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Jie HeThe Second Clinical College of Southern Medical University, Guangzhou, China.
Fangyao ChenDepartment of Biostatistics, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China.
Rongping ChenDepartment of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Hong ChenDepartment of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Southern Medical University · CNZhujiang Hospital · CNSecond Affiliated Hospital of Guangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious clinical trials indicate that probiotic consumption may improve blood glucose control, however, results from randomized trials on glycemic control have been inconsistent.

objectiveTo investigate the effects of probiotics on glycemic control in a systematic review and meta-analysis of randomized controlled trials. DATA SOURCES: PubMed, Embase, Cochrane Library, and Clinicaltrial.gov through October 2014. DATA EXTRACTION AND SYNTHESIS: Two independent reviewers extracted relevant data and assessed study quality and risk of bias. Data were pooled using a random-effects model and expressed as mean differences (MD) with 95% CI. Heterogeneity was assessed (Cochran Q-statistic) and quantified (I2).

resultsSeventeen randomized controlled trials were included, in which 17 fasting blood glucose (n = 1105), 11 fasting plasma insulin (n = 788), 8 homeostasis model assessment of insulin resistance (n = 635) comparisons were reported. Probiotic consumption, compared with placebo, significantly reduced fasting glucose (MD = -0.31 mmol/L; 95% CI 0.56, 0.06; p = 0.02), fasting plasma insulin (MD = -1.29 μU/mL; 95% CI -2.17, -0.41; p = 0.004), and HOMA-IR (MD = 0.48; 95% CI -0.83, -0.13; p = 0.007).

conclusionsProbiotic consumption may improve glycemic control modestly. Modification of gut microbiota by probiotic supplementation may be a method for preventing and control hyperglycemia in clinical practice.

Indexed as

Randomized Controlled Trials as TopicAdolescentAdultAgedBlood GlucoseFastingFemaleHomeostasisHumansHyperglycemiaInsulinInsulin ResistanceMaleMiddle AgedPlacebosProbioticsBlood GlucoseInsulinPlacebos

Identifiers

PMID26161741
PMCPMC4498615
OpenAlexW1479800487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.