ArticlePloS one2015
The Effectiveness of Age-Specific Isolation Policies on Epidemics of Influenza A (H1N1) in a Large City in Central South China.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 27 citations in OpenAlex.
- Evaluating the effects of control interventions and estimating the inapparent infections for dengue outbreak in Hangzhou, China.PloS one · 2019Trial
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- Shigellosis seasonality and transmission characteristics in different areas of China: A modelling study.Infectious Disease Modelling · 2022Article
- Relative transmissibility of shigellosis among different age groups: A modeling study in Hubei Province, China.PLoS neglected tropical diseases · 2021Article
- Estimation of parameters for a humidity-dependent compartmental model of the COVID-19 outbreak.PeerJ · 2021Article
- Feasibility of containing shigellosis in Hubei Province, China: a modelling study.BMC infectious diseases · 2020Article
- A five-compartment model of age-specific transmissibility of SARS-CoV-2.Infectious diseases of poverty · 2020Article
- Relative transmissibility of shigellosis among male and female individuals: a modeling study in Hubei Province, China.Infectious diseases of poverty · 2020Article
- Epidemiological characteristics and transmissibility of shigellosis in Hubei Province, China, 2005 - 2017.BMC infectious diseases · 2020Article
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- Simulation of key interventions for seasonal influenza outbreak control at school in Changsha, China.The Journal of international medical research · 2020Article
- Incidence dynamics and investigation of key interventions in a dengue outbreak in Ningbo City, China.PLoS neglected tropical diseases · 2019Article
- Comparison of methods to Estimate Basic Reproduction Number (Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019Article
- Mobile population dynamics and malaria vulnerability: a modelling study in the China-Myanmar border region of Yunnan Province, China.Infectious diseases of poverty · 2018Article
- The transmissibility estimation of influenza with early stage data of small-scale outbreaks in Changsha, China, 2005-2013.Epidemiology and infection · 2017Article
- Outbreak detection and evaluation of a school-based influenza-like-illness syndromic surveillance in Tianjin, China.PloS one · 2017Article
- Evaluating the effects of common control measures for influenza A (H1N1) outbreak at school in China: A modeling study.PloS one · 2017Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the early stage of a pandemic, isolation is the most effective means of controlling transmission. However, the effectiveness of age-specific isolation policies is not clear; especially little information is available concerning their effectiveness in China. Epidemiological and serological survey data in the city of Changsha were employed to estimate key model parameters. The average infectious period (date of recovery-date of symptom onset) of influenza A (H1N1) was 5.2 days. Of all infected persons, 45.93% were asymptomatic. The basic reproduction number of the influenza A (H1N1) pandemic was 1.82. Based on the natural history of influenza A (H1N1), we built an extended susceptible-exposed-infectious/asymptomatic-removed model, taking age groups: 0-5, 6-14, 15-24, 25-59, and ≥60 years into consideration for isolation. Without interventions, the total attack rates (TARs) in each age group were 42.73%, 41.95%, 20.51%, 45.03%, and 37.49%, respectively. Although the isolation of 25-59 years-old persons was the most effective, the TAR of individuals of aged 0-5 and 6-14 could not be reduced. Paradoxically, isolating individuals ≥60 year olds was not predicted to be an effective way of reducing the TAR in this group but isolating the age-group 25-59 did, which implies inter-age-group transmission from the latter to the former is significant. Isolating multiple age groups increased effectiveness. The most effective combined isolation target groups were of 6-14 + 25-59 year olds, 6-14 + 15-24 + 25-59 year olds, and 0-5 + 6-14 + 25-59 + ≥60 year olds. The last of these isolation schemas reduced the TAR of the total population from 39.64% to 0.006%, which was exceptionally close to the effectiveness of isolating all five age groups (TAR = 0.004%).
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