Evidence map›Paper›PMID 26161626›Full record

ArticleThe Journal of orthopaedic and sports physical therapy2015

Higher Knee Flexion Moment During the Second Half of the Stance Phase of Gait Is Associated With the Progression of Osteoarthritis of the Patellofemoral Joint on Magnetic Resonance Imaging.

Hsiang-Ling Teng, Toran D MacLeod, Thomas M Link, Sharmila Majumdar, Richard B Souza

Registry-linked trialAbstract read
In one paragraph

Article in The Journal of orthopaedic and sports physical therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03663790 (Comparison of the Effects of Gait Modification Strategies on Knee Adduction Moment in Patients With Medial Knee Osteoarthritis), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03663790 narecruitingnot on this mapstarted 2018, after this paper: background citation

Comparison of the Effects of Gait Modification Strategies on Knee Adduction Moment in Patients With Medial Knee Osteoarthritis: Randomized Controlled Trial

TypeinterventionalSponsorGeorge Mason UniversityRan2018 to 2026Enrolled51ConditionsKnee OsteoarthritisArmsFoot Progression, Trunk Lean
3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Effects of TJournal of magnetic resonance imaging : JMRI · 2024
    Article
  12. Inter-joint coordination variability is associated with pain severity and joint loading in persons with knee osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hsiang-Ling TengDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA.
Toran D MacLeod
Thomas M Link
Sharmila Majumdar
Richard B Souza

Funding

MRI TO STUDY CARTILAGE/BONE INTERACTIONSR01AR046905 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 1999 to 2015
$6.3M
Translation of Quantitative Imaging in OsteoarthritisP50AR060752 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2011 to 2015
$6.2M
Contact mechanics, neuromuscular control, and cartilage composition in knee OAR01AR062370 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOUZA, RICHARD BRIAN · 2011 to 2014
$1.1M
NIAMS NIH HHS P50 AR060752NIAMS NIH HHS R01 AR046905NIAMS NIH HHS R01AR046905NIAMS NIH HHS R01 AR062370NIAMS NIH HHS R01AR062370
6 · The paper itself

Abstract

STUDY

designControlled laboratory study, longitudinal design.

objectiveTo examine whether baseline knee flexion moment or impulse during walking is associated with the progression of osteoarthritis (OA) with magnetic resonance imaging of the patellofemoral joint (PFJ) at 1 year.

backgroundPatellofemoral joint OA is highly prevalent and a major source of pain and dysfunction. The biomechanical factors associated with the progression of PFJ OA remain unclear.

methodsThree-dimensional gait analyses were performed at baseline. Magnetic resonance imaging of the knee (high-resolution, 3-D, fast spin-echo sequence) was used to identify PFJ cartilage and bone marrow edema-like lesions at baseline and a 1-year follow-up. The severity of PFJ OA progression was defined using the modified Whole-Organ Magnetic Resonance Imaging Score when new or increased cartilage or bone marrow edema-like lesions were observed at 1 year. Peak external knee flexion moment and flexion moment impulse during the first and second halves of the stance phase of gait were compared between progressors and nonprogressors, and used to predict progression after adjusting for age, sex, body mass index, and presence of baseline PFJ OA.

resultsSixty-one participants with no knee OA or isolated PFJ OA were included. Patellofemoral joint OA progressors (n = 10) demonstrated significantly higher peak knee flexion moment (P = .01) and flexion moment impulse (P = .04) during the second half of stance at baseline compared to nonprogressors. Logistic regression showed that higher peak knee flexion moment during the second half of the stance phase was significantly associated with progression at 1 year (adjusted odds ratio = 3.3, P = .01).

conclusionPeak knee flexion moment and flexion moment impulse during the second half of stance are related to the progression of PFJ OA and may need to be considered when treating individuals who are at risk of or who have PFJ OA.

Indexed as

AdultBiomechanical PhenomenaDisease ProgressionFemaleGaitHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedOsteoarthritis, KneePatellofemoral JointRange of Motion, Articularbone marrow lesionscartilagegaitkineticsWORMS

Identifiers

PMID26161626
PMCPMC4718079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.