ArticlePloS one2015
Against All Odds: Trehalose-6-Phosphate Synthase and Trehalase Genes in the Bdelloid Rotifer Adineta vaga Were Acquired by Horizontal Gene Transfer and Are Upregulated during Desiccation.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Review
- A compendium of horizontal gene transfers in Metazoa.Scientific data · 2026Article
- Haplotype-resolved telomere-to-telomere genome ofGenome research · 2026Article
- The eukaryotic horizontal gene transfer dataset a compendium.bioRxiv : the preprint server for biology · 2025Article
- Cultivation of Bdelloid RotiferBiology · 2025Article
- Does pigmentation provide protection to bdelloid rotifers in a high ultraviolet B environment?Limnology and oceanography · 2024Article
- Ionizing radiation responses appear incidental to desiccation responses in the bdelloid rotifer Adineta vaga.BMC biology · 2024Article
- The nematodePeerJ · 2024Article
- Examination of gammarid transcriptomes reveals a widespread occurrence of key metabolic genes from epibiont bdelloid rotifers in freshwater species.Open biology · 2023Article
- Transcriptomic and Metabolomic Analyses of the Effects of Exogenous Trehalose on Heat Tolerance in Wheat.International journal of molecular sciences · 2022Article
- Horizontal Gene Transfers in Plants.Life (Basel, Switzerland) · 2021Review
- Parallel evolution of trehalose production machinery in anhydrobiotic animals via recurrent gene loss and horizontal transfer.Open biology · 2021Article
- The Evolutionary History and Functional Divergence of Trehalase (Frontiers in physiology · 2019Article
- Review
- Hyperthermal-driven mass extinctions: killing models during the Permian-Triassic mass extinction.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2018Review
- Trehalose metabolism genes render rice white tip nematodeThe Journal of experimental biology · 2018Article
- Trehalose metabolism genes ofBiology open · 2017Article
- No evidence for extensive horizontal gene transfer in the genome of the tardigrade Hypsibius dujardini.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The disaccharide sugar trehalose is essential for desiccation resistance in most metazoans that survive dryness; however, neither trehalose nor the enzymes involved in its metabolism have ever been detected in bdelloid rotifers despite their extreme resistance to desiccation. Here we screened the genome of the bdelloid rotifer Adineta vaga for genes involved in trehalose metabolism. We discovered a total of four putative trehalose-6-phosphate synthase (TPS) and seven putative trehalase (TRE) gene copies in the genome of this ameiotic organism; however, no trehalose-6-phosphate phosphatase (TPP) gene or domain was detected. The four TPS copies of A. vaga appear more closely related to plant and fungi proteins, as well as to some protists, whereas the seven TRE copies fall in bacterial clades. Therefore, A. vaga likely acquired its trehalose biosynthesis and hydrolysis genes by horizontal gene transfers. Nearly all residues important for substrate binding in the predicted TPS domains are highly conserved, supporting the hypothesis that several copies of the genes might be functional. Besides, RNAseq library screening showed that trehalase genes were highly expressed compared to TPS genes, explaining probably why trehalose had not been detected in previous studies of bdelloids. A strong overexpression of their TPS genes was observed when bdelloids enter desiccation, suggesting a possible signaling role of trehalose-6-phosphate or trehalose in this process.
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