Evidence map›Paper›PMID 26161430›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2015

Complement activity is associated with disease severity in multifocal motor neuropathy.

Lotte Vlam, Elisabeth A Cats, Oliver Harschnitz, Marc D Jansen, Sanne Piepers, Jan Herman Veldink, Hessel Franssen, Abraham C J Stork, Erik Heezius, Suzan H M Rooijakkers and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. The Role of Complement Activation in IgM M-Protein-Associated Neuropathies.Neurology(R) neuroimmunology & neuroinflammation · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Immune-Mediated Neuropathies: Pathophysiology and Management.International journal of molecular sciences · 2023
    Review
  10. Therapeutic Monoclonal Antibody Therapies in Chronic Autoimmune Demyelinating Neuropathies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  11. Article
  12. Review
  13. Immune-mediated neuropathies.Nature reviews. Disease primers · 2018
    Review
  14. Review
  15. Human immune globulin infusion in the management of multifocal motor neuropathy.Degenerative neurological and neuromuscular disease · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Lotte VlamBrain Center Rudolf Magnus (L.V., E.A.C., O.H., M.D.J., S.P., J.H.V., H.F., A.C.J.S., L.H.v.d.B., W.L.v.d.P.), Department of Neurology and Department of Medical Microbiology (E.H., S.H.M.R., J.A.v.S.) University Medical Center Utrecht, the Netherlands; and Regional Public Health Laboratory Kennemerland (B.L.H.), Haarlem, the Netherlands.
Elisabeth A CatsBrain Center Rudolf Magnus (L.V., E.A.C., O.H., M.D.J., S.P., J.H.V., H.F., A.C.J.S., L.H.v.d.B., W.L.v.d.P.), Department of Neurology and Department of Medical Microbiology (E.H., S.H.M.R., J.A.v.S.) University Medical Center Utrecht, the Netherlands; and Regional Public Health Laboratory Kennemerland (B.L.H.), Haarlem, the Netherlands.
Oliver HarschnitzBrain Center Rudolf Magnus (L.V., E.A.C., O.H., M.D.J., S.P., J.H.V., H.F., A.C.J.S., L.H.v.d.B., W.L.v.d.P.), Department of Neurology and Department of Medical Microbiology (E.H., S.H.M.R., J.A.v.S.) University Medical Center Utrecht, the Netherlands; and Regional Public Health Laboratory Kennemerland (B.L.H.), Haarlem, the Netherlands.
Marc D JansenBrain Center Rudolf Magnus (L.V., E.A.C., O.H., M.D.J., S.P., J.H.V., H.F., A.C.J.S., L.H.v.d.B., W.L.v.d.P.), Department of Neurology and Department of Medical Microbiology (E.H., S.H.M.R., J.A.v.S.) University Medical Center Utrecht, the Netherlands; and Regional Public Health Laboratory Kennemerland (B.L.H.), Haarlem, the Netherlands.
Sanne PiepersBrain Center Rudolf Magnus (L.V., E.A.C., O.H., M.D.J., S.P., J.H.V., H.F., A.C.J.S., L.H.v.d.B., W.L.v.d.P.), Department of Neurology and Department of Medical Microbiology (E.H., S.H.M.R., J.A.v.S.) University Medical Center Utrecht, the Netherlands; and Regional Public Health Laboratory Kennemerland (B.L.H.), Haarlem, the Netherlands.
Jan Herman VeldinkBrain Center Rudolf Magnus (L.V., E.A.C., O.H., M.D.J., S.P., J.H.V., H.F., A.C.J.S., L.H.v.d.B., W.L.v.d.P.), Department of Neurology and Department of Medical Microbiology (E.H., S.H.M.R., J.A.v.S.) University Medical Center Utrecht, the Netherlands; and Regional Public Health Laboratory Kennemerland (B.L.H.), Haarlem, the Netherlands.
Hessel FranssenBrain Center Rudolf Magnus (L.V., E.A.C., O.H., M.D.J., S.P., J.H.V., H.F., A.C.J.S., L.H.v.d.B., W.L.v.d.P.), Department of Neurology and Department of Medical Microbiology (E.H., S.H.M.R., J.A.v.S.) University Medical Center Utrecht, the Netherlands; and Regional Public Health Laboratory Kennemerland (B.L.H.), Haarlem, the Netherlands.
Abraham C J StorkBrain Center Rudolf Magnus (L.V., E.A.C., O.H., M.D.J., S.P., J.H.V., H.F., A.C.J.S., L.H.v.d.B., W.L.v.d.P.), Department of Neurology and Department of Medical Microbiology (E.H., S.H.M.R., J.A.v.S.) University Medical Center Utrecht, the Netherlands; and Regional Public Health Laboratory Kennemerland (B.L.H.), Haarlem, the Netherlands.
Erik HeeziusBrain Center Rudolf Magnus (L.V., E.A.C., O.H., M.D.J., S.P., J.H.V., H.F., A.C.J.S., L.H.v.d.B., W.L.v.d.P.), Department of Neurology and Department of Medical Microbiology (E.H., S.H.M.R., J.A.v.S.) University Medical Center Utrecht, the Netherlands; and Regional Public Health Laboratory Kennemerland (B.L.H.), Haarlem, the Netherlands.
Suzan H M RooijakkersBrain Center Rudolf Magnus (L.V., E.A.C., O.H., M.D.J., S.P., J.H.V., H.F., A.C.J.S., L.H.v.d.B., W.L.v.d.P.), Department of Neurology and Department of Medical Microbiology (E.H., S.H.M.R., J.A.v.S.) University Medical Center Utrecht, the Netherlands; and Regional Public Health Laboratory Kennemerland (B.L.H.), Haarlem, the Netherlands.
Bjorn L HerpersBrain Center Rudolf Magnus (L.V., E.A.C., O.H., M.D.J., S.P., J.H.V., H.F., A.C.J.S., L.H.v.d.B., W.L.v.d.P.), Department of Neurology and Department of Medical Microbiology (E.H., S.H.M.R., J.A.v.S.) University Medical Center Utrecht, the Netherlands; and Regional Public Health Laboratory Kennemerland (B.L.H.), Haarlem, the Netherlands.
Jos A van StrijpBrain Center Rudolf Magnus (L.V., E.A.C., O.H., M.D.J., S.P., J.H.V., H.F., A.C.J.S., L.H.v.d.B., W.L.v.d.P.), Department of Neurology and Department of Medical Microbiology (E.H., S.H.M.R., J.A.v.S.) University Medical Center Utrecht, the Netherlands; and Regional Public Health Laboratory Kennemerland (B.L.H.), Haarlem, the Netherlands.
Leonard H van den BergBrain Center Rudolf Magnus (L.V., E.A.C., O.H., M.D.J., S.P., J.H.V., H.F., A.C.J.S., L.H.v.d.B., W.L.v.d.P.), Department of Neurology and Department of Medical Microbiology (E.H., S.H.M.R., J.A.v.S.) University Medical Center Utrecht, the Netherlands; and Regional Public Health Laboratory Kennemerland (B.L.H.), Haarlem, the Netherlands.
W Ludo van der PolBrain Center Rudolf Magnus (L.V., E.A.C., O.H., M.D.J., S.P., J.H.V., H.F., A.C.J.S., L.H.v.d.B., W.L.v.d.P.), Department of Neurology and Department of Medical Microbiology (E.H., S.H.M.R., J.A.v.S.) University Medical Center Utrecht, the Netherlands; and Regional Public Health Laboratory Kennemerland (B.L.H.), Haarlem, the Netherlands.
Spaarne Gasthuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether high innate activity of the classical and lectin pathways of complement is associated with multifocal motor neuropathy (MMN) and whether levels of innate complement activity or the potential of anti-GM1 antibodies to activate the complement system correlate with disease severity.

methodsWe performed a case-control study including 79 patients with MMN and 79 matched healthy controls. Muscle weakness was documented with Medical Research Council scale sum score and axonal loss with nerve conduction studies. Activity of the classical and lectin pathways of complement was assessed by ELISA. We also determined serum mannose-binding lectin (MBL) concentrations and polymorphisms in the MBL gene (MBL2) and quantified complement-activating properties of anti-GM1 IgM antibodies by ELISA.

resultsActivity of the classical and lectin pathways, MBL2 genotypes, and serum MBL concentrations did not differ between patients and controls. Complement activation by anti-GM1 IgM antibodies was exclusively mediated through the classical pathway and correlated with antibody titers (p < 0.001). Logistic regression analysis showed that both high innate activity of the classical pathway of complement and high complement-activating capacity of anti-GM1 IgM antibodies were significantly associated with more severe muscle weakness and axonal loss.

conclusionHigh innate activity of the classical pathway of complement and efficient complement-activating properties of anti-GM1 IgM antibodies are determinants of disease severity in patients with MMN. These findings underline the importance of anti-GM1 antibody-mediated complement activation in the pathogenesis and clinical course of MMN.

Identifiers

PMID26161430
PMCPMC4484896
OpenAlexW2149482935

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