Evidence map›Paper›PMID 26161423›Full record

ReviewBioMed research international2015

Human Tumor Antigens and Cancer Immunotherapy.

Nathalie Vigneron

Registry-linked trialAbstract readReview
In one paragraph

Review in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04273061 (Canadian Atezolizumab Precision Targeting for Immunotherapy Intervention), which is not on this map. Cited by 108 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04273061 phase2recruitingnot on this mapstarted 2020, after this paper: background citation

Canadian Atezolizumab Precision Targeting for Immunotherapy Intervention

TypeinterventionalSponsorBritish Columbia Cancer AgencyRan2020 to 2027Enrolled200ConditionsBreast Cancer, Lung Cancer, Gastrointestinal Cancer, Genitourinary CancerArmsAtezolizumab
3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Nathalie VigneronLudwig Institute for Cancer Research, 1200 Brussels, Belgium ; WELBIO (Walloon Excellence in Life Sciences and Biotechnology), 1200 Brussels, Belgium ; de Duve Institute, Université Catholique de Louvain, 1200 Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the recent developments of adoptive T cell therapies and the use of new monoclonal antibodies against the immune checkpoints, immunotherapy is at a turning point. Key players for the success of these therapies are the cytolytic T lymphocytes, which are a subset of T cells able to recognize and kill tumor cells. Here, I review the nature of the antigenic peptides recognized by these T cells and the processes involved in their presentation. I discuss the importance of understanding how each antigenic peptide is processed in the context of immunotherapy and vaccine delivery.

Indexed as

ImmunotherapyAntibodies, MonoclonalAntigens, NeoplasmCancer VaccinesHumansNeoplasmsT-LymphocytesAntibodies, MonoclonalAntigens, NeoplasmCancer Vaccines

Identifiers

PMID26161423
PMCPMC4487697

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.