Evidence map›Paper›PMID 26161394›Full record

ArticleBioMed research international2015

The Effect of C-X-C Motif Chemokine 13 on Hepatocellular Carcinoma Associates with Wnt Signaling.

Chunyan Li, Dong Kang, Xiguang Sun, Yufei Liu, Jinhong Wang, Pujun Gao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Chunyan LiDepartment of Pediatric Respiratory, The First Affiliated Hospital of Jilin University, Changchun 130000, China.
Dong KangHuiqiao Department, South Hospital of Southern Medical University, Guangdong 510000, China.
Xiguang SunDepartment of Hand Surgery, The First Affiliated Hospital of Jilin University, Changchun 130000, China.
Yufei LiuPediatric Digestive Department, The First Affiliated Hospital of Jilin University, Changchun 130000, China.
Jinhong WangDepartment of Respiratory, The Third Affiliated Hospital of Southern Medical University, Guangdong 510000, China.
Pujun GaoDivision of Hepatobiliary and Pancreatic Diseases, The First Affiliated Hospital of Jilin University, Changchun 130000, China.
Jilin University · CNSouthern Medical University · CNThird Affiliated Hospital of Southern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectsTo investigate the effect of CXCL13 (C-X-C motif chemokine 13) on hepatocellular carcinoma and clarify the potential mechanisms.

methods32 patients with hepatocellular carcinoma and 12 healthy controls were recruited for analyzing the expression of CXCL13 by RT-PCR (reverse transcription-polymerase chain reaction). ELISA (enzyme-linked immune-sorbent assay) was used to test the concentration of serum CXCL13. The interaction between CXCL13 and Wnt signaling was analyzed by western blot. In vitro PBMCs cultured with HepG2 supernatant, the levels of IL-12, IL4, IL-6, and IL-17, and four IgG subclasses were detected by ELISA.

resultsThe rate of high expression CXCL13 was 63.4% in advanced HCC patients, and the serum CXCL13 was also at a high level in stage IV HCC patients. Meanwhile CXCL13 level was positively correlated with serum ALT (Alanine Transaminase) and AST (Aspartate Aminotransferase). CXCL13 and Wnt/β-catenin signaling shared a positive feedback loop. Furthermore, CXCL13 could obviously promote the expressions of IL-12 and IL-17, and induce IgG4 secreted by B cells.

conclusionsThe effect of CXCL13 on promoting liver cancer is related to the activation of Wnt/β-catenin pathway and the facilitation of IL-12, IL-17 and IgG4. CXCL13 plays an important role in the progression of HCC, and it may act as a potential target for the diagnosis and treatment of HCC.

Indexed as

AdultAgedbeta CateninB-LymphocytesCarcinogenesisCarcinoma, HepatocellularCell PolarityChemokine CXCL13FemaleHep G2 CellsHumansImmunoglobulin GInterleukin-12Interleukin-17Liver NeoplasmsMalebeta CateninChemokine CXCL13CXCL13 protein, humanImmunoglobulin GInterleukin-12Interleukin-17

Identifiers

PMID26161394
PMCPMC4486493
OpenAlexW1522156216

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.